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PMID: 14676295 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

IL-7 promotes the transition of CD4 effectors to persistent memory cells.

The Journal of experimental medicine ·Vol. 198 ·No. 12 ·2003-12-15 ·Pages 1807-15

Li J, Huston G, Swain SL

Abstract

After transfer to adoptive hosts, in vitro-generated CD4 effectors can become long-lived memory cells, but the factors regulating this transition are unknown. We find that low doses of interleukin (IL) 7 enhance survival of effectors in vitro without driving their division. When in vitro-generated effectors are transferred to normal intact adoptive hosts, they survive and rapidly become small resting cells with a memory phenotype. CD4 effectors generated from wild-type versus IL-7 receptor-/- mice were transferred to adoptive hosts, including intact mice and those deficient in IL-7. In each case, the response to IL-7 was critical for good recovery of donor cells after 5-7 d. Recovery was also IL-7-dependent in Class II hosts where division was minimal. Blocking antibodies to IL-7 dramatically decreased short-term recovery of transferred effectors in vivo without affecting their division. These data indicate that IL-7 plays a critical role in promoting memory CD4 T cell generation by providing survival signals, which allow effectors to successfully become resting memory cells.

MeSH Terms
Adoptive Transfer Animals Apoptosis CD4-Positive T-Lymphocytes/immunology,physiology Cell Survival Immunologic Memory Interleukin-7/physiology Mice Mice, Inbred C57BL Mice, Transgenic Receptors, Antigen, T-Cell/physiology Receptors, Interleukin-7/analysis,physiology
Chemicals
Interleukin-7 Receptors, Antigen, T-Cell Receptors, Interleukin-7
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Li JiChu
Trudeau Institute, Inc, Saranac Lake, NY 12983, USA.
Huston Gail
Swain Susan L
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.20030725
Published
2003-12-15
Pages
1807-15
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2194161
Subset
IM
Grants
NIAID NIH HHS · P01 AI046530 · United States
NIAID NIH HHS · AI26887 · United States
NIAID NIH HHS · AI46530 · United States
External Links
PubMed source DOI: 10.1084/jem.20030725 PMC Full Text View journal details
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