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PMID: 14679171 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Epithelial-mesenchymal transition and its implications for fibrosis.

The Journal of clinical investigation ·Vol. 112 ·No. 12 ·2003-12-00 ·Pages 1776-84

Kalluri R, Neilson EG

Abstract

Epithelial to mesenchymal transition (EMT) is a central mechanism for diversifying the cells found in complex tissues. This dynamic process helps organize the formation of the body plan, and while EMT is well studied in the context of embryonic development, it also plays a role in the genesis of fibroblasts during organ fibrosis in adult tissues. Emerging evidence from studies of renal fibrosis suggests that more than a third of all disease-related fibroblasts originate from tubular epithelia at the site of injury. This review highlights recent advances in the process of EMT signaling in health and disease and how it may be attenuated or reversed by selective cytokines and growth factors.

MeSH Terms
Animals Cytokines/metabolism Epithelium/physiology Fibroblasts/metabolism Fibrosis/pathology Growth Substances Humans Kidney/pathology Kidney Diseases/pathology Mesoderm/physiology Models, Biological Proteome
Chemicals
Cytokines Growth Substances Proteome
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Kalluri Raghu
Center for Matrix Biology, Beth Israel Deaconess Medical Center, 330 Brookline Ave. (DANA 514), Boston, Massachusetts 02215, USA. [email protected]
Neilson Eric G
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI20530
Email
[email protected]
Published
2003-12-00
Pages
1776-84
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC297008
Subset
IM
Grants
NIDDK NIH HHS · DK55001 · United States
NIDDK NIH HHS · DK46282 · United States
NIDDK NIH HHS · R01 DK062987 · United States
NIDDK NIH HHS · R01 DK055001 · United States
NIDDK NIH HHS · R01 DK046282 · United States
NIDDK NIH HHS · DK62987 · United States
External Links
PubMed source DOI: 10.1172/JCI20530 PMC Full Text View journal details
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