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PMID: 14680481 Published · ppublish English Journal Article Review

Deregulation of p27 by oncogenic signaling and its prognostic significance in breast cancer.

Breast cancer research : BCR ·Vol. 6 ·No. 1 ·2004-00-00 ·Pages 13-21

Alkarain A, Slingerland J

Abstract

p27 is a key regulator of progression from G1 to S phase. Although the gene encoding p27 is rarely mutated in human cancers, p27 is functionally inactivated in a majority of human cancers through accelerated p27 proteolysis, through sequestration by cyclin D-cyclin-dependent kinase complexes and by cytoplasmic mislocalization. Here we review mechanisms whereby oncogenic activation of receptor tyrosine kinase and Ras pathways lead to accelerated p27 proteolysis and p27 mislocalization in cancer cells. The prognostic significance of p27 in human breast cancer is also reviewed.

MeSH Terms
Breast Neoplasms/genetics,metabolism,pathology Cell Cycle Proteins/genetics,metabolism Cyclin-Dependent Kinase Inhibitor p27 Cyclin-Dependent Kinases/metabolism Female Gene Expression Regulation, Neoplastic Humans Phosphatidylinositol 3-Kinases/metabolism Prognosis Signal Transduction Survival Analysis Tumor Suppressor Proteins/genetics,metabolism ras Proteins/metabolism
Chemicals
Cell Cycle Proteins Tumor Suppressor Proteins Cyclin-Dependent Kinase Inhibitor p27 Phosphatidylinositol 3-Kinases Cyclin-Dependent Kinases ras Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Alkarain Angel
Braman Breast Cancer Institute, University of Miami School of Medicine, Miami, FL, USA.
Slingerland Joyce
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Article Info
Journal
Breast cancer research : BCR
Abbr.
Breast Cancer Res
ISSN
1465-542X
DOI
10.1186/bcr722
Published
2004-00-00
Epub
2003-00-21
Pages
13-21
Language
English
Region
England
NLM ID
100927353
PMCID
PMC314445
Subset
IM
External Links
PubMed source DOI: 10.1186/bcr722 PMC Full Text View journal details
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