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PMID: 14762118 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Acid-sensing ion channel 2 is important for retinal function and protects against light-induced retinal degeneration.

The Journal of neuroscience : the official journal of the Society for Neuroscience ·Vol. 24 ·No. 5 ·2004-02-04 ·Pages 1005-12

Ettaiche M, Guy N, Hofman P, Lazdunski M, Waldmann R

Abstract

pH variations in the retina are thought to be involved in the fine-tuning of visual perception. We show that both photoreceptors and neurons of the mouse retina express the H+-gated cation channel subunits acid-sensing ion channel 2a (ASIC2a) and ASIC2b. Inactivation of the ASIC2 gene in mice leads to an increase in the rod electroretinogram a- and b-waves and thus to an enhanced gain of visual transduction. ASIC2 knock-out mice are also more sensitive to light-induced retinal degeneration. We suggest that ASIC2 is a negative modulator of rod phototransduction, and that functional ASIC2 channels are beneficial for the maintenance of retinal integrity.

MeSH Terms
Acid Sensing Ion Channels Animals Apoptosis/genetics Blotting, Western DNA Fragmentation/genetics Degenerin Sodium Channels Electroretinography/radiation effects Epithelial Sodium Channels In Situ Hybridization Ion Channels/genetics,metabolism Light/adverse effects Membrane Potentials/genetics,physiology Membrane Proteins/genetics,metabolism Mice Mice, Knockout Nerve Tissue Proteins/genetics,metabolism Neurons/metabolism Photoreceptor Cells/metabolism Protein Isoforms/genetics,metabolism Retina/pathology,physiology,radiation effects Retinal Degeneration/etiology,metabolism,pathology,prevention & control Sodium Channels/genetics,metabolism
Chemicals
ASIC2 protein, mouse Acid Sensing Ion Channels Degenerin Sodium Channels Epithelial Sodium Channels Ion Channels Membrane Proteins Nerve Tissue Proteins Protein Isoforms Sodium Channels
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Ettaiche Mohamed
Institute of Molecular and Cellular Pharmacology, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 6097, Sophia-Antipolis, 06560 Valbonne, France.
Guy Nicolas
Hofman Paul
Lazdunski Michel
Waldmann Rainer
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Article Info
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
Abbr.
J Neurosci
ISSN
1529-2401
DOI
10.1523/JNEUROSCI.4698-03.2004
Published
2004-02-04
Pages
1005-12
Language
English
Region
United States
NLM ID
8102140
PMCID
PMC6793571
Subset
IM
External Links
PubMed source DOI: 10.1523/JNEUROSCI.4698-03.2004 PMC Full Text View journal details
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