Home LiteratureArticle Details
PMID: 14861378 Published · ppublish English Journal Article

Mechanism of production of pulmonary lesions in mice by Newcastle disease virus (NDV).

The Journal of experimental medicine ·Vol. 94 ·No. 3 ·1951-09-00 ·Pages 191-211

GINSBERG HS

Abstract

Infectious NDV particles produce extensive pulmonary consolidation in the mouse in the absence of demonstrable virus multiplication. The lesions are indistinguishable from those of influenza A virus infection. This effect of NDV was blocked by intranasal injection of RDE or immune serum before virus inoculation, but not by immune serum injected 5 minutes or more after NDV. Influenza A virus infection did not diminish fixation of NDV in excised lungs but did interfere with the injurious action of this agent in the living mouse. The analogy between these reactions and those which take place in a progressive virus infection is pointed out, and the mechanism of production of lesions in virus pneumonias discussed.

Keywords
LUNGS NEWCASTLE DISEASE
MeSH Terms
Animals Chickens Immune Sera Influenza A virus Lung Mice Newcastle Disease Newcastle disease virus Virus Replication
Chemicals
Immune Sera
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
GINSBERG H S
References (28)
28 references, click to expand
  1. An improved CO2 cabinet for low temperature storage of infectious agents with gaseous CO2 excluded from the specimen compartment.
    J Bacteriol. 1951 Apr;61(4):443-51 PMID: 14832181
  2. The inhibitory effect of polysaccharide on mumps virus multiplication.
    J Exp Med. 1948 May 1;87(5):385-410 PMID: 18912891
  3. Some Alterations in Chicken Erythrocytes Which Follow Treatment with Influenza and Newcastle Disease Virus.
    J Bacteriol. 1948 Feb;55(2):183-96 PMID: 16561447
  4. The dependence of the pathological lesion upon the multiplication of pneumonia virus of mice (PVM); kinetic relation between the degree of viral multiplication and the extent of pneumonia.
    J Exp Med. 1951 Feb;93(2):139-50 PMID: 14803638
  5. Interference phenomena between animal viruses; a review.
    J Immunol. 1950 Mar;64(3):203-36 PMID: 15412251
  6. The haemolytic action of Newcastle disease virus. I. The two types of interaction between virus and red cell.
    Aust J Exp Biol Med Sci. 1950 May;28(3):299-309 PMID: 14772172
  7. A LATENT VIRUS IN NORMAL MICE CAPABLE OF PRODUCING PNEUMONIA IN ITS NATURAL HOST.
    J Exp Med. 1940 Feb 29;71(3):391-408 PMID: 19870970
  8. The Coagulation of blood: Part II. The actions of snake venoms, peptone and leech extract.
    J Physiol. 1909 Jul 2;38(6):441-503 PMID: 16992964
  9. AN UNIDENTIFIED VIRUS WHICH PRODUCES PNEUMONIA AND SYSTEMIC INFECTION IN MICE.
    Science. 1942 Jan 9;95(2454):49-50 PMID: 17773453
  10. INFLUENCE OF AGE FACTORS ON SUSCEPTIBILITY OF MICE TO RABIES VIRUS.
    J Exp Med. 1940 Sep 30;72(4):445-51 PMID: 19871035
  11. Incomplete growth cycle of influenza virus in mouse brain.
    Proc Soc Exp Biol Med. 1950 Jul;74(3):541-8 PMID: 15440881
  12. The effect of polysaccharides on the reaction between erythrocytes and viruses, with particular reference to mumps virus.
    J Exp Med. 1948 May 1;87(5):411-24 PMID: 18912892
  13. The pathogenesis and pathology of experimental air-borne influenza virus A infections in mice.
    J Infect Dis. 1949 Mar-Apr;84(2):153-68 PMID: 18113780
  14. A STUDY OF VACCINAL IMMUNITY IN TISSUE CULTURES.
    J Exp Med. 1929 Oct 31;50(5):673-85 PMID: 19869654
  15. STUDIES ON THE TOXICITY OF INFLUENZA VIRUSES : I. THE EFFECT OF INTRACEREBRAL INJECTION OF INFLUENZA VIRUSES.
    J Exp Med. 1946 Nov 30;84(6):623-37 PMID: 19871592
  16. Concurrent infection with influenza virus and mumps virus or pneumonia virus of mice as bearing on the inhibition of virus multiplication by bacterial polysaccharides.
    J Exp Med. 1949 Jan;89(1):37-52 PMID: 18099164
  17. STUDIES ON LYMPHOGRANULOMA VENEREUM : II. THE ASSOCIATION OF SPECIFIC TOXINS WITH AGENTS OF THE LYMPHOGRANULOMA-PSITTACOSIS GROUP.
    J Exp Med. 1944 May 1;79(5):463-86 PMID: 19871382
  18. Pathogenesis of coxsackie virus infection; multiplication of virus and evolution of the muscle lesion in mice.
    J Exp Med. 1951 Mar;93(3):247-66 PMID: 14824399
  19. EXPERIMENTAL INFECTION WITH INFLUENZA A VIRUS IN MICE : THE INCREASE IN INTRAPULMONARY VIRUS AFTER INOCULATION AND THE INFLUENCE OF VARIOUS FACTORS THEREON.
    J Exp Med. 1941 Jan 1;73(1):43-55 PMID: 19871064
  20. STUDIES ON THE MECHANISM OF ADAPTATION OF INFLUENZA VIRUS TO MICE.
    J Exp Med. 1947 Oct 31;86(5):357-66 PMID: 19871683
  21. AN ACQUIRED RESISTANCE OF GROWING ANIMALS TO CERTAIN NEUROTROPIC VIRUSES IN THE ABSENCE OF HUMORAL ANTIBODIES OR PREVIOUS EXPOSURE TO INFECTION.
    J Exp Med. 1936 Oct 31;64(5):723-37 PMID: 19870564
  22. AN INFLUENZA VIRUS PNEUMONIA OF MICE THAT IS NONTRANSFERABLE BY SERIAL PASSAGE.
    J Bacteriol. 1949 Apr;57(4):399-403 PMID: 16561710
  23. The relation of the concentration of unadapted and adapted influenza virus in the mouse lung to the death or survival of the infected host.
    J Bacteriol. 1950 Oct;60(4):489-97 PMID: 14784477
  24. ADSORPTION OF INFLUENZA HEMAGGLUTININS AND VIRUS BY RED BLOOD CELLS.
    J Exp Med. 1942 Aug 1;76(2):195-209 PMID: 19871229
  25. A virus recovered from the feces of poliomyelitis patients pathogenic for suckling mice.
    J Exp Med. 1949 Jun 1;89(6):567-82 PMID: 18144319
  26. Interference between inactive and active influenza viruses in the chick embryo. II. The site of interference.
    Aust J Exp Biol Med Sci. 1950 Mar;28(2):231-8 PMID: 14772163
  27. STUDIES ON THE TOXICITY OF INFLUENZA VIRUSES : II. THE EFFECT OF INTRA-ABDOMINAL AND INTRAVENOUS INJECTION OF INFLUENZA VIRUSES.
    J Exp Med. 1946 Nov 30;84(6):639-60 PMID: 19871593
  28. NEUTRALIZATION OF EPIDEMIC INFLUENZA VIRUS : THE LINEAR RELATIONSHIP BETWEEN THE QUANTITY OF SERUM AND THE QUANTITY OF VIRUS NEUTRALIZED.
    J Exp Med. 1939 Jul 31;70(2):209-22 PMID: 19870902
Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.94.3.191
Published
1951-09-00
Pages
191-211
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2136108
Subset
OM
External Links
PubMed source DOI: 10.1084/jem.94.3.191 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2