The enhancing effect of urethane on the severity of infection with pneumonia virus of mice.

The Journal of experimental medicine ·Vol. 95 ·No. 2 ·1952-02-00 ·Pages 147-60

MIRICK GS, SMITH JM, LEFTWICH CI, LEFTWICH WB

Abstract

Urethane, given parenterally or orally to mice, increased the severity of PVM infection. Not only were the lesions more extensive but mice could be infected with smaller inocula of virus and the multiplication of virus in the lung was enhanced. There was atrophy of lymphoid tissues but no suppression was noted of antibody formation. No relation could be found between PVM infection and the development of pulmonary adenomas in mice.

Keywords

PNEUMONIA VIRAL/experimental URETHANE/effects

MeSH Terms

Animals Lung Mice Murine pneumonia virus Pneumonia Pneumonia, Viral Urethane/pharmacology

Chemicals

Urethane

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

MIRICK G S

SMITH J M

LEFTWICH C I

LEFTWICH W B

References (19)

19 references, click to expand

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Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.95.2.147

Published

1952-02-00

Pages

147-60

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2212058

Subset

External Links

PubMed source DOI: 10.1084/jem.95.2.147 PMC Full Text View journal details

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The enhancing effect of urethane on the severity of infection with pneumonia virus of mice.

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