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PMID: 14977174 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

VDAC: the channel at the interface between mitochondria and the cytosol.

Molecular and cellular biochemistry ·Vol. 256-257 ·No. 1-2 ·2004-00-00 ·Pages 107-15

Colombini M

Abstract

The mitochondrial outer membrane is not just a barrier but a site of regulation of mitochondrial function. The VDAC family of proteins are the major pathways for metabolite flux through the outer membrane. These can be regulated in a variety of ways and the integration of these regulatory inputs allows mitochondrial metabolism to be adjusted to changing cellular conditions. This includes total blockage of the flux of anionic metabolites leading to permeabilization of the outer membrane to small proteins followed by apoptotic cell death.

MeSH Terms
Amino Acid Sequence Apoptosis Cytosol/metabolism Ion Channel Gating Mitochondria/metabolism Molecular Sequence Data Porins/chemistry,metabolism,physiology Voltage-Dependent Anion Channels
Chemicals
Porins Voltage-Dependent Anion Channels
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Colombini Marco
Department of Biology, University of Maryland, College Park, MD 20742, USA. [email protected]
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Article Info
Journal
Molecular and cellular biochemistry
Abbr.
Mol Cell Biochem
ISSN
0300-8177
DOI
10.1023/b:mcbi.0000009862.17396.8d
Email
[email protected]
Published
2004-00-00
Pages
107-15
Language
English
Region
Netherlands
NLM ID
0364456
Subset
IM
Grants
NINDS NIH HHS · NS 42025 · United States
External Links
PubMed source DOI: 10.1023/b:mcbi.0000009862.17396.8d View journal details
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