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PMID: 1500204 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

In vivo complement activation and binding of C3 to encapsulated Cryptococcus neoformans.

Infection and immunity ·Vol. 60 ·No. 9 ·1992-09-00 ·Pages 3937-9

Truelsen K, Young T, Kozel TR

Abstract

Tissues from mice infected with Cryptococcus neoformans were examined by immunofluorescence to determine the extent of deposition of complement component C3 on encapsulated cryptococci. The relative percentages of cryptococci in each tissue having readily visible C3 were greatest for liver and lung tissues, with the kidney tissue having the next highest percentage and the spleen having the lowest percentage. Binding of C3 fragments to cryptococci in brain tissue was essentially absent.

MeSH Terms
Animals Complement Activation Complement C3/metabolism Cryptococcus neoformans/immunology Mice Mice, Inbred BALB C
Chemicals
Complement C3
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Truelsen K
Department of Microbiology, University of Nevada, Reno 89557.
Young T
Kozel T R
References (10)
10 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.60.9.3937-3939.1992
Published
1992-09-00
Pages
3937-9
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC257415
Subset
IM
Grants
NIAID NIH HHS · AI 14209 · United States
External Links
PubMed source DOI: 10.1128/iai.60.9.3937-3939.1992 PMC Full Text View journal details
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