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PMID: 15013988 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Sustained lipopolysaccharide-induced lung inflammation in mice is attenuated by functional deficiency of the Fas/Fas ligand system.

Clinical and diagnostic laboratory immunology ·Vol. 11 ·No. 2 ·2004-03-00 ·Pages 358-61

Matute-Bello G, Winn RK, Martin TR, Liles WC

Abstract

To determine whether the Fas/Fas ligand (FasL) (CD95/CD178) system contributes to the development of an inflammatory response in vivo, 2.5 microg of bacterial lipopolysaccharide (LPS; endotoxin) per g was administered intranasally to healthy mice (C57BL/6) and mutant mice deficient in either Fas (lpr mice) or FasL (gld mice). Sustained LPS-induced neutrophilic inflammation in the lungs was attenuated in both lpr and gld mice. These observations provide further evidence of a proinflammatory role for the Fas/FasL system in the lungs.

MeSH Terms
Administration, Intranasal Animals Bronchoalveolar Lavage Fluid/immunology Fas Ligand Protein Lipopolysaccharides/pharmacology Male Membrane Glycoproteins/genetics,immunology,metabolism Mice Mice, Inbred C57BL Mice, Mutant Strains Pneumonia/immunology,pathology,physiopathology fas Receptor/genetics,immunology,metabolism
Chemicals
Fas Ligand Protein Fasl protein, mouse Lipopolysaccharides Membrane Glycoproteins fas Receptor
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Matute-Bello Gustavo
Medical Research Service, VA Puget Sound Health Care System and Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, 98108, USA. [email protected]
Winn Robert K
Martin Thomas R
Liles W Conrad
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Article Info
Journal
Clinical and diagnostic laboratory immunology
Abbr.
Clin Diagn Lab Immunol
ISSN
1071-412X
DOI
10.1128/cdli.11.2.358-361.2004
Email
[email protected]
Published
2004-03-00
Pages
358-61
Language
English
Region
United States
NLM ID
9421292
PMCID
PMC371192
Subset
IM
Grants
NHLBI NIH HHS · HL62995 · United States
NHLBI NIH HHS · R01 HL062995 · United States
NHLBI NIH HHS · HL65892 · United States
NHLBI NIH HHS · HL70840-01 · United States
NHLBI NIH HHS · R01 HL065892 · United States
NHLBI NIH HHS · K08 HL070840 · United States
External Links
PubMed source DOI: 10.1128/cdli.11.2.358-361.2004 PMC Full Text
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