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PMID: 15039373 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Effect of growth state on transcription levels of genes encoding major secreted antigens of Mycobacterium tuberculosis in the mouse lung.

Infection and immunity ·Vol. 72 ·No. 4 ·2004-04-00 ·Pages 2420-4

Shi L, North R, Gennaro ML

Abstract

Arrest of the multiplication of Mycobacterium tuberculosis caused by expression of adaptive immunity in mouse lung was accompanied by a 10- to 20-fold decrease in levels of mRNAs encoding the secreted Ag85 complex and 38-kDa lipoprotein. esat-6 mRNA levels were high throughout infection. The data imply that multiplying and nonreplicating tubercle bacilli have different antigen compositions.

MeSH Terms
Acyltransferases/genetics,metabolism Animals Antigens, Bacterial/genetics,metabolism Bacterial Proteins Gene Expression Regulation, Bacterial Interferon-gamma/genetics Lipoproteins/genetics,metabolism Lung/microbiology Mice Mice, Inbred C57BL Mice, Knockout Mycobacterium tuberculosis/genetics,growth & development,metabolism Transcription, Genetic Tuberculosis, Pulmonary/immunology,microbiology
Chemicals
Antigens, Bacterial Bacterial Proteins ESAT-6 protein, Mycobacterium tuberculosis Lipoproteins Interferon-gamma Acyltransferases antigen 85A, Mycobacterium tuberculosis
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Shi Lanbo
Public Health Research Institute, Newark, New Jersey 07103, USA.
North Robert
Gennaro Maria Laura
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40 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/IAI.72.4.2420-2424.2004
Published
2004-04-00
Pages
2420-4
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC375179
Subset
IM
Grants
NIAID NIH HHS · R01 AI037844 · United States
NIAID NIH HHS · AI-37844 · United States
NIAID NIH HHS · AI-36989 · United States
NIAID NIH HHS · R01 AI036989 · United States
NHLBI NIH HHS · HL-64565 · United States
External Links
PubMed source DOI: 10.1128/IAI.72.4.2420-2424.2004 PMC Full Text View journal details
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