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PMID: 1480113 Published · ppublish English Journal Article Review

The antigen 85 complex: a major secretion product of Mycobacterium tuberculosis.

Microbiological reviews ·Vol. 56 ·No. 4 ·1992-12-00 ·Pages 648-61

Wiker HG, Harboe M

Abstract

The large number of different proteins synthesized by the mycobacterial cell are currently classified and studied in terms of groups of proteins with certain common properties such as physical and chemical characteristics, function, and localization in the mycobacterial cell. Proteins that are actively secreted during culture on synthetic media represent a particular group of great current interest. At least eight proteins secreted by Mycobacterium tuberculosis have been isolated and characterized to various extents. The genes coding for five proteins secreted from M. tuberculosis and/or Mycobacterium bovis BCG have been cloned and sequenced. All of them contain typical signal sequences. The proteins of the antigen 85 complex, which form the main subject of this review, are often the most common proteins in M. tuberculosis culture fluid. The constituents denoted 85A, 85B, and 85C are encoded by three genes located at different sites in the mycobacterial genome and show extensive cross-reactivity as well as homology at amino acid and gene levels. The proteins differ slightly in molecular mass in the 30- to 31-kDa region, and all of them are fibronectin-binding proteins, but the significance of the latter observation and the role of these proteins in mycobacterial physiology and interaction with the infected host remain to be elucidated. The antigen 85 complex proteins are strongly immunogenic in natural and experimental mycobacterial infections in terms of both induction of antibody synthesis and T-cell-mediated reactions. The well-recognized difference in the efficacy of live and dead mycobacterial vaccines should be considered in relation to the group of secreted antigens. After inoculation, live bacteria in vaccines such as BCG multiply in the host, probably releasing several constituents belonging to the class of secreted proteins and hence resulting in more efficient stimulation of the immune system. Secreted mycobacterial antigens are expected to be of particular significance in induction of various immune responses that are responsible for development of protective immunity in some individuals and for clinical symptoms and complications of the ensuing disease in others.

MeSH Terms
Amino Acid Sequence Antigens, Bacterial/metabolism Molecular Sequence Data Mycobacterium tuberculosis/immunology,metabolism
Chemicals
Antigens, Bacterial
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Wiker H G
Institute of Immunology and Rheumatology, University of Oslo, Norway.
Harboe M
References (111)
111 references, click to expand
  1. Specificity and distribution of alpha antigens of Mycobacterium kansasii and Mycobacterium marinum.
    Am Rev Respir Dis. 1984 Oct;130(4):647-9 PMID: 6207754
  2. MPB70, a unique antigen of Mycobacterium bovis BCG.
    Am Rev Respir Dis. 1984 Mar;129(3):444-52 PMID: 6367574
  3. Antibodies to mycobacteria in human tuberculosis. I. Development of antibodies before and after antimicrobial therapy.
    J Infect Dis. 1980 Dec;142(6):825-34 PMID: 6780632
  4. Serologic diagnosis of bone and joint tuberculosis by an enzyme-linked immunosorbent assay.
    J Infect Dis. 1982 Aug;146(2):280-3 PMID: 6809845
  5. Specific skin-reactive protein from culture filtrate of Mycobacterium bovis BCG.
    Infect Immun. 1981 Mar;31(3):1152-60 PMID: 7014457
  6. Serodiagnosis of tuberculosis using the enzyme-linked immunoabsorbent assay (ELISA) of antibody to Mycobacterium tuberculosis antigen 5.
    Am Rev Respir Dis. 1982 Dec;126(6):1013-6 PMID: 7181220
  7. Differential characteristics in vitro and in vivo of several substrains of BCG. IV. Immunizing effectiveness.
    Am Rev Tuberc. 1956 Nov;74(5):699-717 PMID: 13372955
  8. Extracellular proteins of tubercle bacilli. III. Column chromatographical purification of the proteins of a virulent strain (H37Rv) of Mycobacterium tuberculosis.
    Biken J. 1961 Sep;4:187-96 PMID: 13895825
  9. Viability and multiplication of vaccines in immunization against tuberculosis.
    Am Rev Tuberc. 1955 Feb;71(2):228-48 PMID: 14350182
  10. Immunochemical analyses of a major antigen of Mycobacterium szulgai.
    J Infect Dis. 1977 May;135(5):778-86 PMID: 67158
  11. Monoclonal antibody epitopes of mycobacterial 65-kD heat-shock protein defined by epitope scanning.
    Clin Exp Immunol. 1992 Jul;89(1):115-9 PMID: 1378362
  12. The 38-kDa protein of Mycobacterium tuberculosis: a review.
    J Infect Dis. 1992 Oct;166(4):874-84 PMID: 1527425
  13. Modulation of expression of delayed hypersensitivity by mycobacterial antigen 85 fibronectin-binding proteins.
    Infect Immun. 1992 Jun;60(6):2522-8 PMID: 1534074
  14. Protein antigens of mycobacteria studied by quantitative immunologic techniques.
    Clin Infect Dis. 1992 Jan;14(1):313-9 PMID: 1571446
  15. Comparison of the immunological activity of five defined antigens from Mycobacterium tuberculosis in seven inbred guinea pig strains. The 38-kDa antigen is immunodominant.
    Scand J Immunol. 1990 Apr;31(4):503-14 PMID: 1692156
  16. The genes coding for the antigen 85 complexes of Mycobacterium tuberculosis and Mycobacterium bovis BCG are members of a gene family: cloning, sequence determination, and genomic organization of the gene coding for antigen 85-C of M. tuberculosis.
    Infect Immun. 1991 Sep;59(9):3205-12 PMID: 1715324
  17. T lymphocytes mediating protection and cellular cytolysis during the course of Mycobacterium tuberculosis infection. Evidence for different kinetics and recognition of a wide spectrum of protein antigens.
    J Immunol. 1992 Jan 1;148(1):189-96 PMID: 1727865
  18. T-cell proliferative response to antigens secreted by Mycobacterium tuberculosis.
    Infect Immun. 1991 Apr;59(4):1558-63 PMID: 1900811
  19. Genetic analysis of superoxide dismutase, the 23 kilodalton antigen of Mycobacterium tuberculosis.
    Mol Microbiol. 1991 Feb;5(2):381-91 PMID: 1904126
  20. Cloning and expression of the gene for the cross-reactive alpha antigen of Mycobacterium kansasii.
    Infect Immun. 1990 Feb;58(2):550-6 PMID: 2404875
  21. Mycobacterium leprae antigens involved in human immune responses. I. Identification of four antigens by monoclonal antibodies.
    J Immunol. 1985 Dec;135(6):4171-7 PMID: 2415603
  22. The role of activated macrophages in protection and immunopathology in tuberculosis.
    Res Microbiol. 1990 Feb;141(2):253-6 PMID: 2111928
  23. The heat-shock proteins.
    Annu Rev Genet. 1988;22:631-77 PMID: 2853609
  24. Humoral immune response in human tuberculosis: immunoglobulins G, A, and M directed against the purified P32 protein antigen of Mycobacterium bovis bacillus Calmette-Guérin.
    J Clin Microbiol. 1988 Sep;26(9):1714-9 PMID: 3053775
  25. Protein secretion in bacilli.
    Curr Top Microbiol Immunol. 1986;125:103-25 PMID: 3091323
  26. Relation between delayed hypersensitivity and immunity in tuberculosis.
    Am Rev Respir Dis. 1975 Feb;111(2):109-18 PMID: 803355
  27. Immunological studies of an antigen common to many gram-negative bacteria with special reference to E. coli. Characterization and biological significance.
    Int Arch Allergy Appl Immunol. 1975;48(1):72-81 PMID: 803931
  28. High antibody levels to the mycobacterial fibronectin-binding antigen of 30-31 kD in tuberculosis and lepromatous leprosy.
    Clin Exp Immunol. 1992 Mar;87(3):362-7 PMID: 1371953
  29. Isoelectrophoretic characterization of protein antigens present in mycobacterial culture filtrates and recognized by monoclonal antibodies directed against the Mycobacterium bovis BCG antigen 85 complex.
    Scand J Immunol. 1992 Nov;36(5):697-702 PMID: 1439581
  30. A family of cross-reacting proteins secreted by Mycobacterium tuberculosis.
    Scand J Immunol. 1992 Aug;36(2):307-19 PMID: 1502498
  31. Molecular and immunological analysis of a fibronectin-binding protein antigen secreted by Mycobacterium leprae.
    Mol Microbiol. 1992 Jan;6(2):153-63 PMID: 1532043
  32. Mycobacterial protein antigens: a compilation.
    Mol Microbiol. 1992 Jan;6(2):133-45 PMID: 1545700
  33. Structure and function of a 40,000-molecular-weight protein antigen of Mycobacterium tuberculosis.
    Infect Immun. 1992 Jun;60(6):2317-23 PMID: 1587598
  34. Phosphate starvation enhances expression of the immunodominant 38-kilodalton protein antigen of Mycobacterium tuberculosis: demonstration by immunogold electron microscopy.
    Infect Immun. 1992 Jul;60(7):2998-3001 PMID: 1612766
  35. Identification, sequencing, and expression of Mycobacterium leprae superoxide dismutase, a major antigen.
    Infect Immun. 1990 Jun;58(6):1937-42 PMID: 1692812
  36. Humoral immune response of tuberculous patients against the three components of the Mycobacterium bovis BCG 85 complex separated by isoelectric focusing.
    J Clin Microbiol. 1991 Oct;29(10):2348-50 PMID: 1719026
  37. Purification and characterization of the 30,000 dalton native antigen of Mycobacterium tuberculosis and characterization of six monoclonal antibodies reactive with a major epitope of this antigen.
    J Lab Clin Med. 1991 Dec;118(6):589-98 PMID: 1720803
  38. Isolation and partial characterization of major protein antigens in the culture fluid of Mycobacterium tuberculosis.
    Infect Immun. 1991 Jan;59(1):372-82 PMID: 1898899
  39. Proteins released from Mycobacterium tuberculosis during growth.
    Infect Immun. 1991 Jun;59(6):1905-10 PMID: 1903768
  40. Subcellular distribution of monoclonal antibody defined epitopes on immunodominant Mycobacterium tuberculosis proteins in the 30-kDa region: identification and localization of 29/33-kDa doublet proteins on mycobacterial cell wall.
    Scand J Immunol. 1991 Jun;33(6):763-75 PMID: 1904624
  41. Lipoprotein antigens of Mycobacterium tuberculosis.
    Res Microbiol. 1991 Jan;142(1):55-65 PMID: 1906192
  42. A localization index for distinction between extracellular and intracellular antigens of Mycobacterium tuberculosis.
    J Gen Microbiol. 1991 Apr;137(4):875-84 PMID: 1906925
  43. Heat shock proteins: friend and foe?
    Clin Exp Immunol. 1991 Oct;86(1):2-5 PMID: 1914233
  44. T cell response to purified filtrate antigen 85 from Mycobacterium bovis Bacilli Calmette-Guérin (BCG) in leprosy patients.
    Clin Exp Immunol. 1991 Nov;86(2):286-90 PMID: 1934596
  45. Phagocytosis of Mycobacterium tuberculosis is mediated by human monocyte complement receptors and complement component C3.
    J Immunol. 1990 Apr 1;144(7):2771-80 PMID: 2108212
  46. Quantitative and qualitative studies on the major extracellular antigen of Mycobacterium tuberculosis H37Rv and Mycobacterium bovis BCG.
    Am Rev Respir Dis. 1990 Apr;141(4 Pt 1):830-8 PMID: 2109556
  47. Protein synthesis in salivary glands of Drosophila melanogaster: relation to chromosome puffs.
    J Mol Biol. 1974 Apr 15;84(3):389-98 PMID: 4219221
  48. T cell fibronectin: an unexpected inflammatory lymphokine.
    Lymphokine Res. 1990 Fall;9(3):435-47 PMID: 2144604
  49. Heat shock proteins and the immune response.
    Immunol Today. 1990 Apr;11(4):129-36 PMID: 2187470
  50. Protein G-based enzyme-linked immunosorbent assay for anti-MPB70 antibodies in bovine tuberculosis.
    J Clin Microbiol. 1990 May;28(5):913-21 PMID: 2191012
  51. Carrier effect of concanavalin A-reactive and -non-reactive material in tuberculin PPD.
    Scand J Immunol. 1990 Sep;32(3):263-71 PMID: 2402595
  52. Evidence for three separate genes encoding the proteins of the mycobacterial antigen 85 complex.
    Infect Immun. 1990 Jan;58(1):272-4 PMID: 2403534
  53. Specificity and distribution of alpha antigens of Mycobacterium avium-intracellulare, Mycobacterium scrofulaceum, and related species of mycobacteria.
    Am Rev Respir Dis. 1985 Jul;132(1):173-4 PMID: 2409853
  54. Monoclonal antibodies to a 28,000 mol. wt protein antigen of Mycobacterium leprae.
    Clin Exp Immunol. 1985 Jun;60(3):546-52 PMID: 2410167
  55. Interspecies reactivity of five monoclonal antibodies to Mycobacterium tuberculosis as examined by immunoblotting and enzyme-linked immunosorbent assay.
    J Clin Microbiol. 1986 Mar;23(3):446-51 PMID: 2420818
  56. Characterization of antibody-reactive epitopes on the 65-kilodalton protein of Mycobacterium leprae.
    Infect Immun. 1987 Apr;55(4):1000-3 PMID: 2435658
  57. Use of recombinant antigens expressed in Escherichia coli K-12 to map B-cell and T-cell epitopes on the immunodominant 65-kilodalton protein of Mycobacterium bovis BCG.
    Infect Immun. 1988 Jun;56(6):1633-40 PMID: 2453469
  58. Homology of the 70-kilodalton antigens from Mycobacterium leprae and Mycobacterium bovis with the Mycobacterium tuberculosis 71-kilodalton antigen and with the conserved heat shock protein 70 of eucaryotes.
    Infect Immun. 1989 Jan;57(1):204-12 PMID: 2491836
  59. Cloning, sequence determination, and expression of a 32-kilodalton-protein gene of Mycobacterium tuberculosis.
    Infect Immun. 1989 Oct;57(10):3123-30 PMID: 2506131
  60. Structure and mapping of antigenic domains of protein antigen b, a 38,000-molecular-weight protein of Mycobacterium tuberculosis.
    Infect Immun. 1989 Aug;57(8):2481-8 PMID: 2545626
  61. Primary structure of a human mitochondrial protein homologous to the bacterial and plant chaperonins and to the 65-kilodalton mycobacterial antigen.
    Mol Cell Biol. 1989 May;9(5):2279-83 PMID: 2568584
  62. Characterization and taxonomic implications of the rRNA genes of Mycobacterium leprae.
    J Bacteriol. 1989 Jan;171(1):70-3 PMID: 2644213
  63. Effect of zinc deficiency on the appearance of two immunodominant protein antigens (32 kDa and 65 kDa) in culture filtrates of mycobacteria.
    J Gen Microbiol. 1989 Jan;135(1):79-84 PMID: 2674326
  64. Serological response of patients with leprosy to a 28- to 30-kilodalton protein doublet from early cultures of Mycobacterium bovis BCG.
    J Clin Microbiol. 1989 Oct;27(10):2184-9 PMID: 2685019
  65. Cloning and expression of the Mycobacterium bovis BCG gene for extracellular alpha antigen.
    J Bacteriol. 1988 Sep;170(9):3847-54 PMID: 2842287
  66. A frequent HindIII RFLP of the human fibronectin gene (FN1).
    Nucleic Acids Res. 1988 Sep 26;16(18):9074 PMID: 2902575
  67. Immunogenic protein MPB57 from Mycobacterium bovis BCG: molecular cloning, nucleotide sequence and expression.
    FEBS Lett. 1988 Nov 21;240(1-2):115-7 PMID: 3056744
  68. Responsiveness to live M. tuberculosis, and common antigens, of sonicate-stimulated T cell lines from normal donors.
    Clin Exp Immunol. 1986 Jan;63(1):105-10 PMID: 3082544
  69. Mycobacterial growth inhibition by interferon-gamma-activated bone marrow macrophages and differential susceptibility among strains of Mycobacterium tuberculosis.
    J Immunol. 1987 Jun 15;138(12):4408-13 PMID: 3108389
  70. The antigens of Mycobacterium tuberculosis, H37Rv, studied by crossed immunoelectrophoresis. Comparison with a reference system for Mycobacterium bovis, BCG.
    Scand J Immunol. 1988 Feb;27(2):223-39 PMID: 3124264
  71. Characteristics and specificity of acquired immunologic memory to Mycobacterium tuberculosis infection.
    J Immunol. 1988 May 15;140(10):3589-93 PMID: 3129497
  72. Characterization of fibronectin-binding antigens released by Mycobacterium tuberculosis and Mycobacterium bovis BCG.
    Infect Immun. 1988 Dec;56(12):3046-51 PMID: 3141278
  73. Serological responses of patients with lepromatous and tuberculoid leprosy to 30-, 31-, and 32-kilodalton antigens of Mycobacterium tuberculosis.
    J Clin Microbiol. 1988 Oct;26(10):2200-2 PMID: 3141462
  74. A role for heat shock proteins in inflammation?
    Immunol Today. 1988 May;9(5):134-7 PMID: 3256318
  75. Subdivision of daughter strains of bacille Calmette-Guérin (BCG) according to secreted protein patterns.
    J Gen Microbiol. 1986 Nov;132(11):3047-53 PMID: 3305780
  76. Purification and characterization of two protein antigens from the heterogeneous BCG85 complex in Mycobacterium bovis BCG.
    Int Arch Allergy Appl Immunol. 1986;81(4):298-306 PMID: 3536755
  77. Intravesical Bacillus Calmette-Guérin therapy for murine bladder tumors: initiation of the response by fibronectin-mediated attachment of Bacillus Calmette-Guérin.
    Cancer Res. 1987 Apr 1;47(7):1762-6 PMID: 3545453
  78. The serodiagnosis of tuberculosis and other mycobacterial diseases by enzyme-linked immunosorbent assay.
    Am Rev Respir Dis. 1987 May;135(5):1137-51 PMID: 3555188
  79. Serology of tuberculosis. III. Crossed immunoelectrophoretic analysis of sera from tuberculosis and leprosy patients with antigens from BCG.
    Tubercle. 1985 Dec;66(4):277-87 PMID: 3909564
  80. Efficient mapping of protein antigenic determinants.
    Proc Natl Acad Sci U S A. 1986 Sep;83(18):7013-7 PMID: 2428046
  81. Monoclonal antibodies produced in BALB.B10 mice define new antigenic determinants in culture filtrate preparations of Mycobacterium tuberculosis.
    J Clin Microbiol. 1988 Dec;26(12):2608-14 PMID: 2466047
  82. Nucleotide sequence of the 19 kDa antigen gene from Mycobacterium tuberculosis.
    Nucleic Acids Res. 1989 Feb 11;17(3):1249 PMID: 2493628
  83. Characterization of T cell antigens associated with the cell wall protein-peptidoglycan complex of Mycobacterium tuberculosis.
    J Immunol. 1989 Oct 15;143(8):2656-62 PMID: 2507635
  84. Cloning and characterization of the gene for immunogenic protein MPB64 of Mycobacterium bovis BCG.
    Infect Immun. 1989 Jan;57(1):283-8 PMID: 2642468
  85. Complete nucleotide sequence of immunogenic protein MPB70 from Mycobacterium bovis BCG.
    FEMS Microbiol Lett. 1989 Apr;49(2-3):273-6 PMID: 2663636
  86. Identification of cytoplasmic membrane protein antigens of Mycobacterium avium, M. intracellulare, and M. scrofulaceum.
    Can J Microbiol. 1989 May;35(5):529-34 PMID: 2743223
  87. Extracellular proteins of tubercle bacilli. IV. Alpha and beta antigens as major extracellular protein products and as cellular components of a strain (H37Rv) of Mycobacterium tuberculosis.
    Biken J. 1965 Dec;8(4):189-99 PMID: 4955992
  88. A reference system for antigens of Mycobacterium tuberculosis.
    Am Rev Respir Dis. 1971 Oct;104(4):602-4 PMID: 4999283
  89. Purification and antigenic specificity of alpha protein (Yoneda and Fukui) from Mycobacterium tuberculosis and Mycobacterium intracellulare.
    Hiroshima J Med Sci. 1983 Mar;32(1):1-8 PMID: 6190783
  90. Fibronectin and serum amyloid P component stimulate C3b- and C3bi-mediated phagocytosis in cultured human monocytes.
    J Exp Med. 1983 Oct 1;158(4):1338-43 PMID: 6225825
  91. Mechanism of antibiotic resistance in Mycobacterium intracellulare.
    Microbiol Immunol. 1983;27(5):425-31 PMID: 6312275
  92. Immunological evaluation of a component isolated from Mycobacterium bovis BCG with a monoclonal antibody to M. bovis BCG.
    Infect Immun. 1984 Nov;46(2):519-25 PMID: 6389346
  93. Antibodies to mycobacteria in human tuberculosis. II. Response to nine defined mycobacterial antigens with evidence for an antibody common to tuberculosis and lepromatous leprosy.
    J Infect Dis. 1980 Dec;142(6):835-43 PMID: 6780633
  94. Plasma fibronectin enhances phagocytosis of opsonized particles by human peripheral blood monocytes.
    J Exp Med. 1983 Jun 1;157(6):1844-54 PMID: 6854210
  95. The antigens of Mycobacterium bovis, strain BCG, studied by crossed immunoelectrophoresis: a reference system.
    Scand J Immunol. 1980;12(3):249-63 PMID: 7008186
  96. Antigens of PPD, old tuberculin, and autoclaved Mycobacterium bovis BCG studied by crossed immunoelectrophoresis.
    Am Rev Respir Dis. 1981 Jul;124(1):80-7 PMID: 7020505
  97. Antituberculous immunity induced in mice by vaccination with living cultures of attenuated tubercle bacilli.
    J Exp Med. 1953 Feb 1;97(2):207-20 PMID: 13022874
  98. Differential characteristics in vitro and in vivo of several substrains of BCG. I. Multiplication and survival in vitro.
    Am Rev Tuberc. 1956 Nov;74(5):655-66 PMID: 13372952
  99. Vaccination against tuberculosis with nonliving vaccines. I. The problem and its historical background.
    Am Rev Respir Dis. 1959 Oct;80:495-509 PMID: 13843707
  100. THE SEPARATION OF MYCOBACTERIAL ANTIGENS BY ION-EXCHANGE CHROMATOGRAPHY. I. DETAILS OF CHROMATOGRAPHIC AND IMMUNOLOGIC PROCEDURES AND RESULTS WITH FOUR STRAINS OF M. TUBERCULOSIS.
    Am Rev Respir Dis. 1964 Jan;89:29-40 PMID: 14114411
  101. Purification and Characterization of Two Proteins from Culture Filtrates of Mycobacterium tuberculosis H(37)Ra Strain.
    Infect Immun. 1970 Feb;1(2):164-8 PMID: 16557708
  102. Specific lymphoproliferation, gamma interferon production, and serum immunoglobulin G directed against a purified 32 kDa mycobacterial protein antigen (P32) in patients with active tuberculosis.
    Scand J Immunol. 1988 Feb;27(2):187-94 PMID: 3124263
  103. The secreted antigens of Mycobacterium tuberculosis and their relationship to those recognized by the available antibodies.
    J Gen Microbiol. 1988 Feb;134(2):531-8 PMID: 3139828
  104. H-2-linked control of in vitro gamma interferon production in response to a 32-kilodalton antigen (P32) of Mycobacterium bovis bacillus Calmette-Guérin.
    Infect Immun. 1988 Dec;56(12):3196-200 PMID: 3141285
  105. Purification, characterization and identification of a 32 kDa protein antigen of Mycobacterium bovis BCG.
    Microb Pathog. 1987 May;2(5):351-66 PMID: 3148811
  106. Characterization of the secreted antigens of Mycobacterium bovis BCG: comparison of the 46-kilodalton dimeric protein with proteins MPB64 and MPB70.
    Infect Immun. 1987 Dec;55(12):3213-4 PMID: 3316036
  107. MPB59, a widely cross-reacting protein of Mycobacterium bovis BCG.
    Int Arch Allergy Appl Immunol. 1986;81(4):307-14 PMID: 3536756
  108. A family of related ATP-binding subunits coupled to many distinct biological processes in bacteria.
    Nature. 1986 Oct 2-8;323(6087):448-50 PMID: 3762694
  109. Production and partial characterization of monoclonal hybridoma antibodies to Mycobacterium tuberculosis.
    Acta Pathol Microbiol Immunol Scand C. 1985 Dec;93(6):265-72 PMID: 3939074
  110. Isolation, purification, and characterization of extracellular antigens of Mycobacterium tuberculosis.
    Am Rev Respir Dis. 1965 Dec;92(6):9-18 PMID: 4954240
  111. Extracellular proteins of tubercle bacilli. V. Distribution of alpha and beta antigens in various mycobacteria.
    Biken J. 1965 Dec;8(4):201-23 PMID: 5865487
Article Info
Journal
Microbiological reviews
Abbr.
Microbiol Rev
ISSN
0146-0749
DOI
10.1128/mr.56.4.648-661.1992
Published
1992-12-00
Pages
648-61
Language
English
Region
United States
NLM ID
7806086
PMCID
PMC372892
Subset
IM
External Links
PubMed source DOI: 10.1128/mr.56.4.648-661.1992 PMC Full Text
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