Inconsistent bactericidal activity of triple-combination therapy with vancomycin, ampicillin, and gentamicin against vancomycin-resistant, highly ampicillin-resistant Enterococcus faecium.

Antimicrobial agents and chemotherapy ·Vol. 36 ·No. 7 ·1992-07-00 ·Pages 1563-6

Fraimow HS, Venuti E

Abstract

Combination therapy with ampicillin, vancomycin, and gentamicin in vitro against several clinical isolates of vancomycin-resistant, highly ampicillin-resistant Enterococcus faecium, including VanA and VanB strains, was evaluated. The MICs of ampicillin were not significantly decreased by induction with vancomycin, and the combination of ampicillin and vancomycin was not inhibitory for any strain. Triple-combination therapy was least active against highly resistant VanA isolates, achieving a reduction of less than 1 log CFU at 24 h, but demonstrated slightly more activity against VanB strains.

MeSH Terms

Ampicillin/pharmacology Ampicillin Resistance Drug Resistance, Microbial Drug Therapy, Combination Enterococcus faecium/drug effects,isolation & purification Gentamicins/pharmacology Humans Microbial Sensitivity Tests Vancomycin/pharmacology

Chemicals

Gentamicins Vancomycin Ampicillin

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Fraimow H S

Division of Infectious Disease, Jefferson Medical College, Philadelphia, Pennsylvania 19107.

Venuti E

References (10)

10 references, click to expand

Inducible carboxypeptidase activity in vancomycin-resistant enterococci.
Antimicrob Agents Chemother. 1992 Jan;36(1):77-80 PMID: 1534213
Identification of vancomycin resistance protein VanA as a D-alanine:D-alanine ligase of altered substrate specificity.
Biochemistry. 1991 Feb 26;30(8):2017-21 PMID: 1998664
Vancomycin-resistant enterococci.
Lancet. 1988 Jan 2-9;1(8575-6):57-8 PMID: 2891921
One or two low affinity penicillin-binding proteins may be responsible for the range of susceptibility of Enterococcus faecium to benzylpenicillin.
J Gen Microbiol. 1985 Aug;131(8):1933-40 PMID: 3850924
Recovery of resistant enterococci during vancomycin prophylaxis.
J Clin Microbiol. 1988 Jun;26(6):1216-8 PMID: 3384933
Effects of combinations of beta-lactams, daptomycin, gentamicin, and glycopeptides against glycopeptide-resistant enterococci.
Antimicrob Agents Chemother. 1991 Jan;35(1):92-8 PMID: 1849711
Triple-combination penicillin-vancomycin-gentamicin for experimental endocarditis caused by a moderately penicillin- and highly glycopeptide-resistant isolate of Enterococcus faecium.
J Infect Dis. 1991 Nov;164(5):888-93 PMID: 1940467
Synergistic killing of vancomycin-resistant enterococci of classes A, B, and C by combinations of vancomycin, penicillin, and gentamicin.
Antimicrob Agents Chemother. 1991 Apr;35(4):776-9 PMID: 2069388
Resistance to vancomycin and teicoplanin: an emerging clinical problem.
Clin Microbiol Rev. 1990 Jul;3(3):280-91 PMID: 2143434
Concomitant high-level vancomycin and penicillin resistance in clinical isolates of enterococci.
Clin Infect Dis. 1992 Mar;14(3):655-61 PMID: 1562656

Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.36.7.1563

Published

1992-07-00

Pages

1563-6

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC191621

Subset

External Links

PubMed source DOI: 10.1128/AAC.36.7.1563 PMC Full Text View journal details

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Inconsistent bactericidal activity of triple-combination therapy with vancomycin, ampicillin, and gentamicin against vancomycin-resistant, highly ampicillin-resistant Enterococcus faecium.

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