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PMID: 15142257 Published · ppublish English Journal Article Review

Chemokine blockade: a new era in the treatment of rheumatoid arthritis?

Arthritis research & therapy ·Vol. 6 ·No. 3 ·2004-00-00 ·Pages 93-7

Haringman JJ, Tak PP

Abstract

Blockade of chemokines or chemokine receptors is emerging as a new potential treatment for various immune-mediated conditions. This review focuses on the therapeutic potential in rheumatoid arthritis, based on studies in animal models and patients. Several knockout models as well as in vivo use of chemokine antagonists are discussed. Review of these data suggests that this approach might lead to novel therapeutic strategies in rheumatoid arthritis and other chronic inflammatory disorders.

MeSH Terms
Animals Arthritis, Rheumatoid/drug therapy Chemokines/antagonists & inhibitors Humans
Chemicals
Chemokines
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Haringman Jasper J
Division of Clinical Immunology and Rheumatology, Academic Medical Centre/University of Amsterdam, Amsterdam, The Netherlands.
Tak Paul P
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33 references, click to expand
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Article Info
Journal
Arthritis research & therapy
Abbr.
Arthritis Res Ther
ISSN
1478-6362
DOI
10.1186/ar1172
Published
2004-00-00
Epub
2004-00-01
Pages
93-7
Language
English
Region
England
NLM ID
101154438
PMCID
PMC416447
Subset
IM
External Links
PubMed source DOI: 10.1186/ar1172 PMC Full Text View journal details
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