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PMID: 15166154 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

The genetics of inviability and male sterility in hybrids between Anopheles gambiae and An. arabiensis.

Genetics ·Vol. 167 ·No. 1 ·2004-05-00 ·Pages 275-87

Slotman M, Della Torre A, Powell JR

Abstract

Male hybrids between Anopheles gambiae and An. arabiensis suffer from hybrid sterility, and inviability effects are sometimes present as well. We examined the genetic basis of these reproductive barriers between the two species, using 21 microsatellite markers. Generally, recessive inviability effects were found on the X chromosome of gambiae that are incompatible with at least one factor on each arabiensis autosome. Inviability is complete when the gambiae and arabiensis inviability factors are hemi- or homozygous. Using a QTL mapping approach, regions that contribute to male hybrid sterility were also identified. The X chromosome has a disproportionately large effect on male hybrid sterility. Additionally, several moderate-to-large autosomal QTL were found in both species. The effect of these autosomal QTL is contingent upon the presence of an X chromosome from the other species. Substantial regions of the autosomes do not contribute markedly to male hybrid sterility. Finally, no evidence for epistatic interactions between conspecific sterility loci was found.

MeSH Terms
Animals Anopheles/genetics,physiology Chimera/genetics,physiology Chromosome Mapping Crosses, Genetic Epistasis, Genetic Female Genetic Markers Homozygote Infertility, Male Male Microsatellite Repeats Models, Genetic Phenotype Quantitative Trait Loci Species Specificity X Chromosome
Chemicals
Genetic Markers
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Slotman M
Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut 06511-7444, USA. [email protected]
Della Torre A
Powell J R
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Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
0016-6731
DOI
10.1534/genetics.167.1.275
Email
[email protected]
Published
2004-05-00
Pages
275-87
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC1470845
Subset
IM
Grants
PHS HHS · R01 46018 · United States
External Links
PubMed source DOI: 10.1534/genetics.167.1.275 PMC Full Text View journal details
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