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PMID: 15175321 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

MacA, a diheme c-type cytochrome involved in Fe(III) reduction by Geobacter sulfurreducens.

Journal of bacteriology ·Vol. 186 ·No. 12 ·2004-06-00 ·Pages 4042-5

Butler JE, Kaufmann F, Coppi MV, Núñez C, Lovley DR

Abstract

A 36-kDa diheme c-type cytochrome abundant in Fe(III)-respiring Geobacter sulfurreducens, designated MacA, was more highly expressed during growth with Fe(III) as the electron acceptor than with fumarate. Although MacA has homology to proteins with in vitro peroxidase activity, deletion of macA had no impact on response to oxidative stress. However, the capacity for Fe(III) reduction was greatly diminished, indicating that MacA, which is predicted to be localized in the periplasm, is a key intermediate in electron transfer to Fe(III).

MeSH Terms
Amino Acid Sequence Bacterial Proteins/genetics,metabolism Cytochrome c Group/genetics,metabolism Deltaproteobacteria/enzymology,growth & development Electron Transport Ferric Compounds/metabolism Gene Deletion Molecular Sequence Data Oxidation-Reduction
Chemicals
Bacterial Proteins Cytochrome c Group Ferric Compounds
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Butler Jessica E
Department of Microbiology, 203 Morrill Science Center IVN, University of Massachusetts Amherst, Amherst, MA 01003, USA.
Kaufmann Franz
Coppi Maddalena V
Núñez Cinthia
Lovley Derek R
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/JB.186.12.4042-4045.2004
Published
2004-06-00
Pages
4042-5
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC419948
Subset
IM
External Links
PubMed source DOI: 10.1128/JB.186.12.4042-4045.2004 PMC Full Text View journal details
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