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PMID: 15240829 Published · epublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Demarcating the gene-rich regions of the wheat genome.

Nucleic acids research ·Vol. 32 ·No. 12 ·2004-00-00 ·Pages 3546-65

Erayman M, Sandhu D, Sidhu D, Dilbirligi M, Baenziger PS, Gill KS

Abstract

By physically mapping 3025 loci including 252 phenotypically characterized genes and 17 quantitative trait loci (QTLs) relative to 334 deletion breakpoints, we localized the gene-containing fraction to 29% of the wheat genome present as 18 major and 30 minor gene-rich regions (GRRs). The GRRs varied both in gene number and density. The five largest GRRs physically spanning <3% of the genome contained 26% of the wheat genes. Approximate size of the GRRs ranged from 3 to 71 Mb. Recombination mainly occurred in the GRRs. Various GRRs varied as much as 128-fold for gene density and 140-fold for recombination rates. Except for a general suppression in 25-40% of the chromosomal region around centromeres, no correlation of recombination was observed with the gene density, the size, or chromosomal location of GRRs. More than 30% of the wheat genes are in recombination-poor regions thus are inaccessible to map-based cloning.

MeSH Terms
Chromosome Mapping DNA, Plant/analysis Genes, Plant Genetic Markers Genome, Plant Phenotype Physical Chromosome Mapping Quantitative Trait Loci Recombination, Genetic Triticum/genetics
Chemicals
DNA, Plant Genetic Markers
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Erayman Mustafa
Washington State University, Pullman, WA 99164, USA.
Sandhu Devinder
Sidhu Deepak
Dilbirligi Muharrem
Baenziger P S
Gill Kulvinder S
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
1362-4962
DOI
10.1093/nar/gkh639
Published
2004-00-00
Epub
2004-00-07
Pages
3546-65
Language
English
Region
England
NLM ID
0411011
PMCID
PMC484162
Subset
IM
External Links
PubMed source DOI: 10.1093/nar/gkh639 PMC Full Text View journal details
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