Home LiteratureArticle Details
PMID: 15242934 Published · ppublish English Journal Article Review

Targeting CD40L: a promising therapeutic approach.

Clinical and diagnostic laboratory immunology ·Vol. 11 ·No. 4 ·2004-07-00 ·Pages 635-41

Daoussis D, Andonopoulos AP, Liossis SN

Abstract

暂无摘要

MeSH Terms
Animals Antigen-Presenting Cells/immunology CD40 Ligand/immunology Humans Lymphocyte Activation/immunology T-Lymphocytes/immunology
Chemicals
CD40 Ligand
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Daoussis Dimitris
Division of Rheumatology, Department of Internal Medicine, Patras University Hospital, University of Patras Medical School, Patras, Greece.
Andonopoulos Andrew P
Liossis Stamatis-Nick C
References (69)
69 references, click to expand
  1. Immune cell signaling aberrations in human lupus.
    Immunol Res. 1998 Aug;18(1):27-39 PMID: 9724847
  2. Peripheral blood lymphocytes in SLE--hyperexpression of CD154 on T and B lymphocytes and increased number of double negative T cells.
    J Autoimmun. 1998 Oct;11(5):471-5 PMID: 9802931
  3. Human Th1 responses driven by IL-12 are associated with enhanced expression of CD40 ligand.
    Clin Exp Immunol. 1999 Jan;115(1):78-85 PMID: 9933423
  4. Immune cell signaling defects in lupus: activation, anergy and death.
    Immunol Today. 1999 Mar;20(3):119-24 PMID: 10203702
  5. Elevated levels and functional capacity of soluble CD40 ligand in systemic lupus erythematosus sera.
    Arthritis Rheum. 1999 May;42(5):871-81 PMID: 10323442
  6. Aberrant expression of the costimulatory molecule CD40 ligand on monocytes from patients with systemic lupus erythematosus.
    Clin Immunol. 2002 Apr;103(1):54-62 PMID: 11987985
  7. CD154 is expressed during treatment with calcineurin inhibitors after organ transplantation.
    Transplantation. 2002 May 27;73(10):1666-72 PMID: 12042657
  8. The effect of anti-CD40 ligand antibody on B cells in human systemic lupus erythematosus.
    Arthritis Rheum. 2002 Jun;46(6):1554-62 PMID: 12115186
  9. Ligation of CD40 induced tumor necrosis factor-alpha in rheumatoid arthritis: a novel mechanism of activation of synoviocytes.
    J Rheumatol. 1999 May;26(5):1035-43 PMID: 10332965
  10. Cutting edge: CD40 ligand is a limiting factor in the humoral response to T cell-dependent antigens.
    J Immunol. 1999 Aug 1;163(3):1123-7 PMID: 10415005
  11. Human endothelial cells augment early CD40 ligand expression in activated CD4+ T cells through LFA-3-mediated stabilization of mRNA.
    J Immunol. 1999 Sep 1;163(5):2667-73 PMID: 10453007
  12. Human rheumatoid factor production is dependent on CD40 signaling and autoantigen.
    J Immunol. 1999 Sep 15;163(6):3116-22 PMID: 10477577
  13. The soluble CD40 ligand sCD154 in systemic lupus erythematosus.
    J Clin Invest. 1999 Oct;104(7):947-55 PMID: 10510335
  14. Increased expression of CD40 ligand (CD154) on CD4+ T cells as a marker of disease activity in rheumatoid arthritis.
    Ann Rheum Dis. 2000 Mar;59(3):190-5 PMID: 10700427
  15. IL-2 and IL-15 regulate CD154 expression on activated CD4 T cells.
    J Immunol. 2000 Apr 1;164(7):3500-5 PMID: 10725703
  16. The roles of CD28 and CD40 ligand in T cell activation and tolerance.
    J Immunol. 2000 May 1;164(9):4465-70 PMID: 10779746
  17. CD40 engagement on synovial fibroblast up-regulates production of vascular endothelial growth factor.
    J Immunol. 2000 May 15;164(10):5055-61 PMID: 10799861
  18. Increased CD40 expression on muscle cells of polymyositis and dermatomyositis: role of CD40-CD40 ligand interaction in IL-6, IL-8, IL-15, and monocyte chemoattractant protein-1 production.
    J Immunol. 2000 Jun 15;164(12):6593-600 PMID: 10843719
  19. Inhibition of p38 MAP kinase as a therapeutic strategy.
    Immunopharmacology. 2000 May;47(2-3):185-201 PMID: 10878289
  20. Heightened CD40 ligand gene expression in peripheral CD4+ T cells from patients with kidney allograft rejection.
    Transplantation. 2000 Aug 15;70(3):497-505 PMID: 10949194
  21. The emerging role of CD40 ligand in HIV infection.
    J Leukoc Biol. 2000 Sep;68(3):373-82 PMID: 10985254
  22. The role of CD40 ligand and tumor necrosis factor alpha signaling in the transgenic K/BxN mouse model of rheumatoid arthritis.
    Arthritis Rheum. 2000 Nov;43(11):2571-7 PMID: 11083282
  23. Regulatory defects in Cbl and mitogen-activated protein kinase (extracellular signal-related kinase) pathways cause persistent hyperexpression of CD40 ligand in human lupus T cells.
    J Immunol. 2000 Dec 1;165(11):6627-34 PMID: 11086108
  24. CD40 ligand in CLL pathogenesis and therapy.
    Leuk Lymphoma. 2000 May;37(5-6):461-72 PMID: 11042507
  25. Trichostatin A reverses skewed expression of CD154, interleukin-10, and interferon-gamma gene and protein expression in lupus T cells.
    Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2628-33 PMID: 11226290
  26. Expression of costimulatory molecules on peripheral blood lymphocytes of patients with systemic lupus erythematosus.
    Ann Rheum Dis. 2001 May;60(5):523-6 PMID: 11302879
  27. ICOS is critical for CD40-mediated antibody class switching.
    Nature. 2001 Jan 4;409(6816):102-5 PMID: 11343122
  28. ICOS is essential for effective T-helper-cell responses.
    Nature. 2001 Jan 4;409(6816):105-9 PMID: 11343123
  29. Fibrosis of the lung and other tissues: new concepts in pathogenesis and treatment.
    Clin Immunol. 2001 Jun;99(3):308-19 PMID: 11358425
  30. Advances in transplantation tolerance.
    Lancet. 2001 Jun 16;357(9272):1959-63 PMID: 11425437
  31. Successful conversion from conventional immunosuppression to anti-CD154 monoclonal antibody costimulatory molecule blockade in rhesus renal allograft recipients.
    Transplantation. 2001 Aug 27;72(4):587-97 PMID: 11544416
  32. Regulation of CD40 ligand expression in systemic lupus erythematosus.
    Curr Opin Rheumatol. 2001 Sep;13(5):361-9 PMID: 11604589
  33. CD40 signaling and plaque instability.
    Circ Res. 2001 Dec 7;89(12):1092-103 PMID: 11739273
  34. Cutting Edge: Ectopic expression of CD40 ligand on B cells induces lupus-like autoimmune disease.
    J Immunol. 2002 Jan 1;168(1):9-12 PMID: 11751940
  35. CD40 ligation induces macrophage IL-10 and TNF-alpha production: differential use of the PI3K and p42/44 MAPK-pathways.
    Cytokine. 2001 Nov 21;16(4):131-42 PMID: 11792123
  36. Expression of CD40 ligand (CD154) in B and T lymphocytes of Hodgkin disease: potential therapeutic significance.
    Cancer. 2002 Jan 1;94(1):1-5 PMID: 11815953
  37. Mechanism of action of combined short-term CTLA4Ig and anti-CD40 ligand in murine systemic lupus erythematosus.
    J Immunol. 2002 Feb 15;168(4):2046-53 PMID: 11823542
  38. Activation and inhibition of lymphocytes by costimulation.
    J Clin Invest. 2002 Feb;109(3):295-9 PMID: 11827987
  39. Expression of CD40 and CD40 ligand among cell populations within rheumatoid synovial compartment.
    Autoimmunity. 2001;34(2):107-13 PMID: 11905840
  40. CD40 ligand immunotherapy in cancer: an efficient approach.
    Leuk Lymphoma. 2001 Nov-Dec;42(6):1367-77 PMID: 11911421
  41. CD40-CD40L interaction in Alzheimer's disease.
    Curr Opin Pharmacol. 2002 Aug;2(4):445-51 PMID: 12127879
  42. CD40L overexpression on T cells and monocytes from patients with systemic lupus erythematosus is resistant to calcineurin inhibition.
    Lupus. 2002;11(6):370-8 PMID: 12139375
  43. Novel therapeutic agents for systemic lupus erythematosus.
    Curr Opin Rheumatol. 2002 Sep;14(5):515-21 PMID: 12192247
  44. New insights into the interactions between T-cell costimulatory blockade and conventional immunosuppressive drugs.
    Ann Surg. 2002 Nov;236(5):667-75 PMID: 12409674
  45. An expanding role for CD40L and other tumor necrosis factor superfamily ligands in HIV infection.
    J Hematother Stem Cell Res. 2002 Oct;11(5):787-801 PMID: 12427285
  46. Treatment of systemic lupus erythematosus by inhibition of T cell costimulation with anti-CD154: a randomized, double-blind, placebo-controlled trial.
    Arthritis Rheum. 2002 Dec;46(12):3251-8 PMID: 12483729
  47. Effects of anti-CD154 treatment on B cells in murine systemic lupus erythematosus.
    Arthritis Rheum. 2003 Feb;48(2):495-506 PMID: 12571860
  48. Histone deacetylase inhibitors modulate renal disease in the MRL-lpr/lpr mouse.
    J Clin Invest. 2003 Feb;111(4):539-52 PMID: 12588892
  49. A short course of BG9588 (anti-CD40 ligand antibody) improves serologic activity and decreases hematuria in patients with proliferative lupus glomerulonephritis.
    Arthritis Rheum. 2003 Mar;48(3):719-27 PMID: 12632425
  50. Reconstitution of deficient T cell receptor zeta chain restores T cell signaling and augments T cell receptor/CD3-induced interleukin-2 production in patients with systemic lupus erythematosus.
    Arthritis Rheum. 2003 Jul;48(7):1948-55 PMID: 12847689
  51. CD40 ligand is selectively expressed on CD4+ T cells and platelets: implications for CD40-CD40L signalling in atherosclerosis.
    J Pathol. 2003 Oct;201(2):288-95 PMID: 14517846
  52. Abnormal germinal center reactions in systemic lupus erythematosus demonstrated by blockade of CD154-CD40 interactions.
    J Clin Invest. 2003 Nov;112(10):1506-20 PMID: 14617752
  53. Expression of CD154 (CD40 ligand) by human lung fibroblasts: differential regulation by IFN-gamma and IL-13, and implications for fibrosis.
    J Immunol. 2004 Feb 1;172(3):1862-71 PMID: 14734771
  54. The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome.
    Cell. 1993 Jan 29;72(2):291-300 PMID: 7678782
  55. Prevention of collagen-induced arthritis with an antibody to gp39, the ligand for CD40.
    Science. 1993 Sep 3;261(5126):1328-30 PMID: 7689748
  56. In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. II. Prolonged suppression of the humoral immune response by an antibody to the ligand for CD40, gp39.
    J Exp Med. 1993 Nov 1;178(5):1567-75 PMID: 7693850
  57. Ligation of B7 with CD28/CTLA-4 on T cells results in CD40 ligand expression, interleukin-4 secretion and efficient help for antibody production by B cells.
    Eur J Immunol. 1993 Dec;23(12):3120-5 PMID: 7504989
  58. Cyclosporin A inhibits CD40 ligand expression in T lymphocytes.
    J Clin Invest. 1994 Mar;93(3):1315-20 PMID: 7907604
  59. TCR/CD3 complex-mediated signal transduction pathway in T cells and T cell lines from patients with systemic lupus erythematosus.
    J Immunol. 1995 Aug 15;155(4):2269-81 PMID: 7636273
  60. Functional interactions of T cells with endothelial cells: the role of CD40L-CD40-mediated signals.
    J Exp Med. 1995 Dec 1;182(6):1857-64 PMID: 7500031
  61. Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion.
    J Exp Med. 1996 Feb 1;183(2):693-8 PMID: 8627184
  62. Hyperexpression of CD40 ligand by B and T cells in human lupus and its role in pathogenic autoantibody production.
    J Clin Invest. 1996 May 1;97(9):2063-73 PMID: 8621796
  63. Increased expression of CD40 ligand on systemic lupus erythematosus lymphocytes.
    J Clin Invest. 1996 Aug 1;98(3):826-37 PMID: 8698875
  64. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.
    J Exp Med. 1996 Aug 1;184(2):747-52 PMID: 8760829
  65. B cells from patients with systemic lupus erythematosus display abnormal antigen receptor-mediated early signal transduction events.
    J Clin Invest. 1996 Dec 1;98(11):2549-57 PMID: 8958217
  66. Functional CD40 ligand is expressed by T cells in rheumatoid arthritis.
    J Clin Invest. 1997 Nov 1;100(9):2404-14 PMID: 9410920
  67. Altered pattern of TCR/CD3-mediated protein-tyrosyl phosphorylation in T cells from patients with systemic lupus erythematosus. Deficient expression of the T cell receptor zeta chain.
    J Clin Invest. 1998 Apr 1;101(7):1448-57 PMID: 9525988
  68. IL-12 up-regulates CD40 ligand (CD154) expression on human T cells.
    J Immunol. 1998 Feb 1;160(3):1166-72 PMID: 9570530
  69. CD40 signaling in vascular cells: a key role in atherosclerosis?
    Atherosclerosis. 1998 Apr;137 Suppl:S89-95 PMID: 9694547
Article Info
Journal
Clinical and diagnostic laboratory immunology
Abbr.
Clin Diagn Lab Immunol
ISSN
1071-412X
Published
2004-07-00
Pages
635-41
Language
English
Region
United States
NLM ID
9421292
PMCID
PMC440614
Subset
IM
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]