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Immune cell signaling aberrations in human lupus.
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Peripheral blood lymphocytes in SLE--hyperexpression of CD154 on T and B lymphocytes and increased number of double negative T cells.
J Autoimmun. 1998 Oct;11(5):471-5
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Human Th1 responses driven by IL-12 are associated with enhanced expression of CD40 ligand.
Clin Exp Immunol. 1999 Jan;115(1):78-85
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Immune cell signaling defects in lupus: activation, anergy and death.
Immunol Today. 1999 Mar;20(3):119-24
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Elevated levels and functional capacity of soluble CD40 ligand in systemic lupus erythematosus sera.
Arthritis Rheum. 1999 May;42(5):871-81
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Aberrant expression of the costimulatory molecule CD40 ligand on monocytes from patients with systemic lupus erythematosus.
Clin Immunol. 2002 Apr;103(1):54-62
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CD154 is expressed during treatment with calcineurin inhibitors after organ transplantation.
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The effect of anti-CD40 ligand antibody on B cells in human systemic lupus erythematosus.
Arthritis Rheum. 2002 Jun;46(6):1554-62
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Ligation of CD40 induced tumor necrosis factor-alpha in rheumatoid arthritis: a novel mechanism of activation of synoviocytes.
J Rheumatol. 1999 May;26(5):1035-43
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Cutting edge: CD40 ligand is a limiting factor in the humoral response to T cell-dependent antigens.
J Immunol. 1999 Aug 1;163(3):1123-7
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Human endothelial cells augment early CD40 ligand expression in activated CD4+ T cells through LFA-3-mediated stabilization of mRNA.
J Immunol. 1999 Sep 1;163(5):2667-73
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Human rheumatoid factor production is dependent on CD40 signaling and autoantigen.
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The soluble CD40 ligand sCD154 in systemic lupus erythematosus.
J Clin Invest. 1999 Oct;104(7):947-55
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Increased expression of CD40 ligand (CD154) on CD4+ T cells as a marker of disease activity in rheumatoid arthritis.
Ann Rheum Dis. 2000 Mar;59(3):190-5
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IL-2 and IL-15 regulate CD154 expression on activated CD4 T cells.
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The roles of CD28 and CD40 ligand in T cell activation and tolerance.
J Immunol. 2000 May 1;164(9):4465-70
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CD40 engagement on synovial fibroblast up-regulates production of vascular endothelial growth factor.
J Immunol. 2000 May 15;164(10):5055-61
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Increased CD40 expression on muscle cells of polymyositis and dermatomyositis: role of CD40-CD40 ligand interaction in IL-6, IL-8, IL-15, and monocyte chemoattractant protein-1 production.
J Immunol. 2000 Jun 15;164(12):6593-600
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Inhibition of p38 MAP kinase as a therapeutic strategy.
Immunopharmacology. 2000 May;47(2-3):185-201
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Heightened CD40 ligand gene expression in peripheral CD4+ T cells from patients with kidney allograft rejection.
Transplantation. 2000 Aug 15;70(3):497-505
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The emerging role of CD40 ligand in HIV infection.
J Leukoc Biol. 2000 Sep;68(3):373-82
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The role of CD40 ligand and tumor necrosis factor alpha signaling in the transgenic K/BxN mouse model of rheumatoid arthritis.
Arthritis Rheum. 2000 Nov;43(11):2571-7
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Regulatory defects in Cbl and mitogen-activated protein kinase (extracellular signal-related kinase) pathways cause persistent hyperexpression of CD40 ligand in human lupus T cells.
J Immunol. 2000 Dec 1;165(11):6627-34
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CD40 ligand in CLL pathogenesis and therapy.
Leuk Lymphoma. 2000 May;37(5-6):461-72
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Trichostatin A reverses skewed expression of CD154, interleukin-10, and interferon-gamma gene and protein expression in lupus T cells.
Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2628-33
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Expression of costimulatory molecules on peripheral blood lymphocytes of patients with systemic lupus erythematosus.
Ann Rheum Dis. 2001 May;60(5):523-6
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ICOS is critical for CD40-mediated antibody class switching.
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ICOS is essential for effective T-helper-cell responses.
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Fibrosis of the lung and other tissues: new concepts in pathogenesis and treatment.
Clin Immunol. 2001 Jun;99(3):308-19
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Advances in transplantation tolerance.
Lancet. 2001 Jun 16;357(9272):1959-63
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Successful conversion from conventional immunosuppression to anti-CD154 monoclonal antibody costimulatory molecule blockade in rhesus renal allograft recipients.
Transplantation. 2001 Aug 27;72(4):587-97
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Regulation of CD40 ligand expression in systemic lupus erythematosus.
Curr Opin Rheumatol. 2001 Sep;13(5):361-9
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CD40 signaling and plaque instability.
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Cutting Edge: Ectopic expression of CD40 ligand on B cells induces lupus-like autoimmune disease.
J Immunol. 2002 Jan 1;168(1):9-12
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CD40 ligation induces macrophage IL-10 and TNF-alpha production: differential use of the PI3K and p42/44 MAPK-pathways.
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Expression of CD40 ligand (CD154) in B and T lymphocytes of Hodgkin disease: potential therapeutic significance.
Cancer. 2002 Jan 1;94(1):1-5
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Mechanism of action of combined short-term CTLA4Ig and anti-CD40 ligand in murine systemic lupus erythematosus.
J Immunol. 2002 Feb 15;168(4):2046-53
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Activation and inhibition of lymphocytes by costimulation.
J Clin Invest. 2002 Feb;109(3):295-9
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Expression of CD40 and CD40 ligand among cell populations within rheumatoid synovial compartment.
Autoimmunity. 2001;34(2):107-13
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CD40 ligand immunotherapy in cancer: an efficient approach.
Leuk Lymphoma. 2001 Nov-Dec;42(6):1367-77
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CD40-CD40L interaction in Alzheimer's disease.
Curr Opin Pharmacol. 2002 Aug;2(4):445-51
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CD40L overexpression on T cells and monocytes from patients with systemic lupus erythematosus is resistant to calcineurin inhibition.
Lupus. 2002;11(6):370-8
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Novel therapeutic agents for systemic lupus erythematosus.
Curr Opin Rheumatol. 2002 Sep;14(5):515-21
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New insights into the interactions between T-cell costimulatory blockade and conventional immunosuppressive drugs.
Ann Surg. 2002 Nov;236(5):667-75
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An expanding role for CD40L and other tumor necrosis factor superfamily ligands in HIV infection.
J Hematother Stem Cell Res. 2002 Oct;11(5):787-801
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Treatment of systemic lupus erythematosus by inhibition of T cell costimulation with anti-CD154: a randomized, double-blind, placebo-controlled trial.
Arthritis Rheum. 2002 Dec;46(12):3251-8
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Effects of anti-CD154 treatment on B cells in murine systemic lupus erythematosus.
Arthritis Rheum. 2003 Feb;48(2):495-506
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Histone deacetylase inhibitors modulate renal disease in the MRL-lpr/lpr mouse.
J Clin Invest. 2003 Feb;111(4):539-52
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A short course of BG9588 (anti-CD40 ligand antibody) improves serologic activity and decreases hematuria in patients with proliferative lupus glomerulonephritis.
Arthritis Rheum. 2003 Mar;48(3):719-27
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Reconstitution of deficient T cell receptor zeta chain restores T cell signaling and augments T cell receptor/CD3-induced interleukin-2 production in patients with systemic lupus erythematosus.
Arthritis Rheum. 2003 Jul;48(7):1948-55
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CD40 ligand is selectively expressed on CD4+ T cells and platelets: implications for CD40-CD40L signalling in atherosclerosis.
J Pathol. 2003 Oct;201(2):288-95
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Abnormal germinal center reactions in systemic lupus erythematosus demonstrated by blockade of CD154-CD40 interactions.
J Clin Invest. 2003 Nov;112(10):1506-20
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Expression of CD154 (CD40 ligand) by human lung fibroblasts: differential regulation by IFN-gamma and IL-13, and implications for fibrosis.
J Immunol. 2004 Feb 1;172(3):1862-71
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The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome.
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Prevention of collagen-induced arthritis with an antibody to gp39, the ligand for CD40.
Science. 1993 Sep 3;261(5126):1328-30
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In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. II. Prolonged suppression of the humoral immune response by an antibody to the ligand for CD40, gp39.
J Exp Med. 1993 Nov 1;178(5):1567-75
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Ligation of B7 with CD28/CTLA-4 on T cells results in CD40 ligand expression, interleukin-4 secretion and efficient help for antibody production by B cells.
Eur J Immunol. 1993 Dec;23(12):3120-5
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Cyclosporin A inhibits CD40 ligand expression in T lymphocytes.
J Clin Invest. 1994 Mar;93(3):1315-20
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TCR/CD3 complex-mediated signal transduction pathway in T cells and T cell lines from patients with systemic lupus erythematosus.
J Immunol. 1995 Aug 15;155(4):2269-81
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Functional interactions of T cells with endothelial cells: the role of CD40L-CD40-mediated signals.
J Exp Med. 1995 Dec 1;182(6):1857-64
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Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion.
J Exp Med. 1996 Feb 1;183(2):693-8
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Hyperexpression of CD40 ligand by B and T cells in human lupus and its role in pathogenic autoantibody production.
J Clin Invest. 1996 May 1;97(9):2063-73
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Increased expression of CD40 ligand on systemic lupus erythematosus lymphocytes.
J Clin Invest. 1996 Aug 1;98(3):826-37
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Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.
J Exp Med. 1996 Aug 1;184(2):747-52
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B cells from patients with systemic lupus erythematosus display abnormal antigen receptor-mediated early signal transduction events.
J Clin Invest. 1996 Dec 1;98(11):2549-57
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Functional CD40 ligand is expressed by T cells in rheumatoid arthritis.
J Clin Invest. 1997 Nov 1;100(9):2404-14
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Altered pattern of TCR/CD3-mediated protein-tyrosyl phosphorylation in T cells from patients with systemic lupus erythematosus. Deficient expression of the T cell receptor zeta chain.
J Clin Invest. 1998 Apr 1;101(7):1448-57
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IL-12 up-regulates CD40 ligand (CD154) expression on human T cells.
J Immunol. 1998 Feb 1;160(3):1166-72
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CD40 signaling in vascular cells: a key role in atherosclerosis?
Atherosclerosis. 1998 Apr;137 Suppl:S89-95
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