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PMID: 1531345 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Platelet-derived growth factor promotes smooth muscle migration and intimal thickening in a rat model of balloon angioplasty.

The Journal of clinical investigation ·Vol. 89 ·No. 2 ·1992-02-00 ·Pages 507-11

Jawien A, Bowen-Pope DF, Lindner V, Schwartz SM, Clowes AW

Abstract

Platelet-derived growth factor (PDGF) is a mitogen and chemoattractant for vascular smooth muscle cells (SMC) in vitro, but its activities in vivo remain largely undefined. We infused recombinant PDGF-BB (0.01-0.30 mg/kg per d i.v.) into rats subjected to carotid injury. PDGF-BB produced a small increase (two- to threefold) in medial SMC proliferation. More importantly, PDGF-BB greatly increased (20-fold) the intimal thickening and the migration of SMC from the media to the intima during the first 7 d after injury. These data provide support for the hypothesis that PDGF, and perhaps other platelet factors, might play an important role in the movement of mesenchymal cells into zones of injury undergoing repair.

MeSH Terms
Angioplasty, Balloon Animals Cell Division/drug effects Cell Movement/drug effects Hyperplasia In Vitro Techniques Male Muscle, Smooth, Vascular/drug effects,pathology Platelet-Derived Growth Factor/pharmacology,physiology Rats Rats, Inbred Strains Recombinant Proteins/pharmacology
Chemicals
Platelet-Derived Growth Factor Recombinant Proteins
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Jawien A
Department of Surgery, University of Washington School of Medicine, Seattle 98195.
Bowen-Pope D F
Lindner V
Schwartz S M
Clowes A W
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI115613
Published
1992-02-00
Pages
507-11
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC442880
Subset
IM
Grants
NIGMS NIH HHS · GM-35501 · United States
NHLBI NIH HHS · HL-42270 · United States
External Links
PubMed source DOI: 10.1172/JCI115613 PMC Full Text View journal details
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