Home LiteratureArticle Details
PMID: 1549069 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Recombinant epidermolytic (exfoliative) toxin A of Staphylococcus aureus is not a superantigen.

Medical microbiology and immunology ·Vol. 180 ·No. 6 ·1992-00-00 ·Pages 273-8

Fleischer B, Bailey CJ

Abstract

The epidermolytic (exfoliative) toxins produced by Staphylococcus aureus cause epidermolysis and skin blistering. In addition, they have been implicated to belong to the group of T lymphocyte stimulating molecules known as "superantigens". Here we show that recombinant epidermolytic toxin A produced in S. aureus is not mitogenic for human and murine T lymphocytes. We discuss the possibility that minute contaminations of highly mitogenic exoproteins may cause the mitogenicity in several proteins that are reported to be superantigens.

MeSH Terms
Animals Antigens, Bacterial/immunology Blotting, Western Cells, Cultured Cloning, Molecular Exfoliatins/immunology Humans Interleukin-2/analysis Lymphocyte Activation Mice Mice, Inbred BALB C Monocytes Recombinant Proteins/immunology Spleen/cytology Staphylococcus aureus/immunology T-Lymphocytes/immunology
Chemicals
Antigens, Bacterial Exfoliatins Interleukin-2 Recombinant Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Fleischer B
Department of Medicine, University of Mainz, Federal Republic of Germany.
Bailey C J
References (16)
16 references, click to expand
  1. Superantigenicity of streptococcal M protein.
    J Exp Med. 1990 Jul 1;172(1):359-62 PMID: 2358781
  2. HLA-DR alleles differ in their ability to present staphylococcal enterotoxins to T cells.
    J Exp Med. 1990 Sep 1;172(3):709-17 PMID: 2117633
  3. An evolutionary conserved mechanism of T cell activation by microbial toxins. Evidence for different affinities of T cell receptor-toxin interaction.
    J Immunol. 1991 Jan 1;146(1):11-7 PMID: 1670601
  4. Interaction of Staphylococcus aureus toxin "superantigens" with human T cells.
    Proc Natl Acad Sci U S A. 1989 Nov;86(22):8941-5 PMID: 2479030
  5. A comparative study of two serotypes of epidermolytic toxin from Staphylococcus aureus.
    Biochim Biophys Acta. 1980 Jul 24;624(1):111-20 PMID: 6773585
  6. The staphylococcal enterotoxins and their relatives.
    Science. 1990 May 11;248(4956):705-11 PMID: 2185544
  7. Mitogenic activity of staphylococcal exfoliative toxin.
    Infect Immun. 1980 Nov;30(2):381-4 PMID: 7439984
  8. Nucleotide sequence of the epidermolytic toxin A gene of Staphylococcus aureus.
    J Bacteriol. 1987 Sep;169(9):3910-5 PMID: 3040667
  9. Molecular cloning and expression of the epidermolytic toxin A gene of Staphylococcus aureus.
    Microb Pathog. 1986 Dec;1(6):583-94 PMID: 3508500
  10. A superantigen encoded in the open reading frame of the 3' long terminal repeat of mouse mammary tumour virus.
    Nature. 1991 Mar 21;350(6315):203-7 PMID: 1706480
  11. Bacterial toxins as probes for the T-cell antigen receptor.
    Immunol Today. 1989 Aug;10(8):262-4 PMID: 2803504
  12. Superantigens: mechanism of T-cell stimulation and role in immune responses.
    Annu Rev Immunol. 1991;9:745-72 PMID: 1832875
  13. Mitogenic activity of staphylococcal protein A is due to contaminating staphylococcal enterotoxins.
    J Immunol Methods. 1987 Dec 4;105(1):133-7 PMID: 3500237
  14. Different staphylococcal enterotoxins bind preferentially to distinct major histocompatibility complex class II isotypes.
    Eur J Immunol. 1989 Nov;19(11):2171-4 PMID: 2599004
  15. Staphylococcal protein A (SpA) does not induce production of interferon-gamma in human mononuclear blood cells.
    Cell Immunol. 1984 Jun;86(1):136-44 PMID: 6426804
  16. Clonal deletion of V beta 14-bearing T cells in mice transgenic for mammary tumour virus.
    Nature. 1991 Mar 21;350(6315):207-11 PMID: 1848685
Article Info
Journal
Medical microbiology and immunology
Abbr.
Med Microbiol Immunol
ISSN
0300-8584
DOI
10.1007/BF00191548
Published
1992-00-00
Pages
273-8
Language
English
Region
Germany
NLM ID
0314524
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00191548 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2