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PMID: 15504881 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

In vitro pharmacodynamic characteristics of amphotericin B, caspofungin, fluconazole, and voriconazole against bloodstream isolates of infrequent Candida species from patients with hematologic malignancies.

Antimicrobial agents and chemotherapy ·Vol. 48 ·No. 11 ·2004-11-00 ·Pages 4453-6

Di Bonaventura G, Spedicato I, Picciani C, D'Antonio D, Piccolomini R

Abstract

Time-kill and postantifungal effect (PAFE) of amphotericin B, caspofungin, fluconazole, and voriconazole were determined against clinical isolates of Candida guilliermondii, Candida kefyr, and Candida lusitaniae. Azoles displayed fungistatic activity and no measurable PAFE, regardless of the concentration tested. Amphotericin B and caspofungin demonstrated concentration-dependent fungicidal activity, although amphotericin B only produced a significant dose-dependent PAFE against all isolates tested.

MeSH Terms
Amphotericin B/pharmacology Antifungal Agents/pharmacology Candida/drug effects Candidiasis/complications,microbiology Caspofungin Colony Count, Microbial Echinocandins Fluconazole/pharmacology Hematologic Neoplasms/complications Humans Kinetics Lipopeptides Microbial Sensitivity Tests Models, Biological Peptides, Cyclic/pharmacology Pyrimidines/pharmacology Triazoles/pharmacology Voriconazole
Chemicals
Antifungal Agents Echinocandins Lipopeptides Peptides, Cyclic Pyrimidines Triazoles Amphotericin B Fluconazole Caspofungin Voriconazole
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Di Bonaventura Giovanni
Center of Excellence on Aging, Room 27, 5th level, "G. D'Annunzio" University, Via Colle dell'Ara, 66100 Chieti, Italy.
Spedicato Ilaria
Picciani Carla
D'Antonio Domenico
Piccolomini Raffaele
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.48.11.4453-4456.2004
Published
2004-11-00
Pages
4453-6
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC525414
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.48.11.4453-4456.2004 PMC Full Text View journal details
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