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PMID: 15520849 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

CD4+ Tregs and immune control.

The Journal of clinical investigation ·Vol. 114 ·No. 9 ·2004-11-00 ·Pages 1209-17

Fehérvari Z, Sakaguchi S

Abstract

Recent years have seen Tregs become a popular subject of immunological research. Abundant experimental data have now confirmed that naturally occurring CD25+CD4+ Tregs in particular play a key role in the maintenance of self tolerance, with their dysfunction leading to severe or even fatal immunopathology. The sphere of influence of Tregs is now known to extend well beyond just the maintenance of immunological tolerance and to impinge on a host of clinically important areas from cancer to infectious diseases. The identification of specific molecular markers in both human and murine immune systems has enabled the unprecedented investigation of these cells and should prove key to ultimately unlocking their clinical potential.

MeSH Terms
Animals CD4-Positive T-Lymphocytes/physiology Forkhead Transcription Factors Humans Immune System/physiology Immune Tolerance Ligands Mice Models, Biological Phenotype Receptors, Interleukin-2/biosynthesis Repressor Proteins/metabolism T-Lymphocytes, Regulatory/physiology Thymus Gland/metabolism,physiology
Chemicals
FOXP1 protein, human Forkhead Transcription Factors Ligands Receptors, Interleukin-2 Repressor Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Fehérvari Zoltán
Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan. [email protected]
Sakaguchi Shimon
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI23395
Email
[email protected]
Published
2004-11-00
Pages
1209-17
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC524236
Subset
IM
External Links
PubMed source DOI: 10.1172/JCI23395 PMC Full Text View journal details
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