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PMID: 15536567 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Detection of a new cerebral malaria susceptibility locus, using CBA mice.

Immunogenetics ·Vol. 56 ·No. 9 ·2004-12-00 ·Pages 675-8

Ohno T, Nishimura M

Abstract

Human cerebral malaria (CM) during acute Plasmodium falciparum infection is a serious neurological complication that leads to coma and death. P. berghei ANKA infection of CBA mice is a useful experimental model of CM. To identify host susceptibility loci, we performed chromosomal mapping in crossbred populations of both CM-susceptible CBA and CM-resistant DBA/2 mice. One significant region for a CM-susceptible locus in CBA mice was mapped to H2 region on Chromosome 17, tentatively designated cmsc. cmsc was mapped to a different chromosomal region from that previously reported in the C57BL/6 mouse model of CM. It is possible that different loci contribute to CM in CBA and C57BL/6 mouse strains. Comparison of the function of CM susceptibility loci between CBA and C57BL/6 mice could have important implications for the study of the complex pathogenesis of CM in humans.

MeSH Terms
Animals Chi-Square Distribution Chromosome Mapping Genetic Markers Genetic Predisposition to Disease Malaria, Cerebral/genetics,immunology Mice Mice, Inbred CBA Plasmodium berghei/immunology
Chemicals
Genetic Markers
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Ohno Tamio
Division of Experimental Animals, Center for Promotion of Medical Research and Education, Graduate School of Medicine, Nagoya University, Showa-ku, Nagoya 466-8550, Japan. [email protected]
Nishimura Masahiko
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Article Info
Journal
Immunogenetics
Abbr.
Immunogenetics
ISSN
0093-7711
DOI
10.1007/s00251-004-0739-1
Email
[email protected]
Published
2004-12-00
Epub
2004-00-06
Pages
675-8
Language
English
Region
United States
NLM ID
0420404
Subset
IM
External Links
PubMed source DOI: 10.1007/s00251-004-0739-1 View journal details
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