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PMID: 155928 Published · ppublish English Journal Article

Argyrophil pituitary tumors showing TSH cells or small granule cells.

Virchows Archiv. A, Pathological anatomy and histology ·Vol. 381 ·No. 3 ·1979-03-23 ·Pages 295-312

Capella C, Usellini L, Frigerio B, Buffa R, Fontana P, Solcia E

Abstract

Among 74 histochemically and ultrastructurally studied pituitary adenomas, 12 apparently chromophobe tumors were characterized by the presence of numerous argyrophil cells. All these argyrophil adenomas failed to reveal presence of GH, prolactin or ACTH cells. Two tumors were found to consist of well granulated cells reacting intensely with anti-TSH antibodies and resembling TSH cells of the normal pituitary. The remaining argyrophil adenomas did not show TSH immunostaining and, with one exception, failed to react with an anti-HCG serum staining gonadotroph cells of human pituitary. They were composed of small, closely apposed cells with small compact or vesicular granules. These tumor cells seem to correspond to some small argyrophil cells found in non-neoplastic pituitary, which differ from TSH cells and from all other types of functionally identified adenohypophyseal cells.

MeSH Terms
Adenoma, Chromophobe/ultrastructure Adult Aged Female Humans Male Microscopy, Electron Middle Aged Pituitary Neoplasms/analysis,pathology,ultrastructure Thyrotropin/analysis
Chemicals
Thyrotropin
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Capella C
Usellini L
Frigerio B
Buffa R
Fontana P
Solcia E
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46 references, click to expand
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Article Info
Journal
Virchows Archiv. A, Pathological anatomy and histology
Abbr.
Virchows Arch A Pathol Anat Histol
ISSN
0340-1227
DOI
10.1007/BF00432473
Published
1979-03-23
Pages
295-312
Language
English
Region
Germany
NLM ID
7505137
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00432473
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