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PMID: 15608630 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

High frequency, synchronized bursting drives eye-specific segregation of retinogeniculate projections.

Nature neuroscience ·Vol. 8 ·No. 1 ·2005-01-00 ·Pages 72-8

Torborg CL, Hansen KA, Feller MB

Abstract

Blockade of retinal waves prevents the segregation of retinogeniculate afferents into eye-specific layers in the visual thalamus. However, the key features of retinal waves that drive this refinement are controversial. Some manipulations of retinal waves lead to normal eye-specific segregation but others do not. By comparing retinal spiking patterns in several mutant mice with differing levels of eye-specific segregation, we show that the presence of high-frequency bursts synchronized across neighboring retinal ganglion cells correlates with robust eye-specific segregation and that the presence of high levels of asynchronous spikes does not inhibit this segregation. These findings provide a possible resolution to previously described discrepancies regarding the role of retinal waves in retinogeniculate segregation.

MeSH Terms
Action Potentials Animals Connexins/deficiency,physiology Electrophysiology Geniculate Bodies/physiology Mice Mice, Knockout Ocular Physiological Phenomena Reaction Time Receptors, Nicotinic/deficiency,physiology Retina/physiology Retinal Ganglion Cells/physiology Synaptic Transmission/physiology
Chemicals
Connexins Receptors, Nicotinic connexin 36 nicotinic receptor beta2
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Torborg Christine L
Neurobiology Section, Division of Biological Sciences, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093-0357, USA.
Hansen Kristi A
Feller Marla B
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Article Info
Journal
Nature neuroscience
Abbr.
Nat Neurosci
ISSN
1097-6256
DOI
10.1038/nn1376
Published
2005-01-00
Epub
2004-00-19
Pages
72-8
Language
English
Region
United States
NLM ID
9809671
PMCID
PMC1463890
Subset
IM
Grants
NEI NIH HHS · R01 EY013528 · United States
NINDS NIH HHS · NS13528-01A1 · United States
Corrections
ErratumIn
-
External Links
PubMed source DOI: 10.1038/nn1376 PMC Full Text View journal details
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