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PMID: 15611928 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Fine mapping and positional candidate studies identify HLA-G as an asthma susceptibility gene on chromosome 6p21.

American journal of human genetics ·Vol. 76 ·No. 2 ·2005-02-00 ·Pages 349-57

Nicolae D, Cox NJ, Lester LA, Schneider D, Tan Z, Billstrand C, Kuldanek S, Donfack J, Kogut P, Patel NM, Goodenbour J, Howard T, Wolf R, Koppelman GH, White SR, Parry R, Postma DS, Meyers D, Bleecker ER, Hunt JS, Solway J, Ober C

Abstract

Asthma affects nearly 14 million people worldwide and has been steadily increasing in frequency for the past 50 years. Although environmental factors clearly influence the onset, progression, and severity of this disease, family and twin studies indicate that genetic variation also influences susceptibility. Linkage of asthma and related phenotypes to chromosome 6p21 has been reported in seven genome screens, making it the most replicated region of the genome. However, because many genes with individually small effects are likely to contribute to risk, identification of asthma susceptibility loci has been challenging. In this study, we present evidence from four independent samples in support of HLA-G as a novel asthma and bronchial hyperresponsiveness susceptibility gene in the human leukocyte antigen region on chromosome 6p21, and we speculate that this gene might contribute to risk for other inflammatory diseases that show linkage to this region.

MeSH Terms
Adult Asthma/genetics Bronchial Hyperreactivity/genetics Child Chromosome Mapping Chromosomes, Human, Pair 6/genetics Female Genetic Predisposition to Disease Genetic Testing HLA Antigens/genetics HLA-G Antigens Histocompatibility Antigens Class I/genetics Humans Male Phenotype
Chemicals
HLA Antigens HLA-G Antigens Histocompatibility Antigens Class I
Authors & Affiliations
22 authors, click to expand affiliations / ORCID
Nicolae Dan
Department of Statistics, The University of Chicago, Chicago, IL, USA.
Cox Nancy J
Lester Lucille A
Schneider Daniel
Tan Zheng
Billstrand Christine
Kuldanek Susan
Donfack Joseph
Kogut Paul
Patel Nina M
Goodenbour Jeffrey
Howard Timothy
Wolf Raoul
Koppelman Gerard H
White Steven R
Parry Rodney
Postma Dirkje S
Meyers Deborah
Bleecker Eugene R
Hunt Joan S
Solway Julian
Ober Carole
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Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
DOI
10.1086/427763
Published
2005-02-00
Epub
2004-00-20
Pages
349-57
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC1196380
Subset
IM
Grants
NHLBI NIH HHS · HL66393 · United States
NHLBI NIH HHS · HL56399 · United States
NHLBI NIH HHS · R01 HL066533 · United States
NHLBI NIH HHS · HL72414 · United States
NCRR NIH HHS · M01 RR000055 · United States
NHLBI NIH HHS · R01 HL072414 · United States
NHLBI NIH HHS · R01 HL066393 · United States
NHLBI NIH HHS · P50 HL056399 · United States
NHLBI NIH HHS · HL66533 · United States
External Links
PubMed source DOI: 10.1086/427763 PMC Full Text View journal details
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