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PMID: 15642180 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, P.H.S. Review

New highlights on stroma-epithelial interactions in breast cancer.

Breast cancer research : BCR ·Vol. 7 ·No. 1 ·2005-00-00 ·Pages 33-6

Barcellos-Hoff MH, Medina D

Abstract

Although the stroma in which carcinomas arise has been previously regarded as a bystander to the clonal expansion and acquisition of malignant characteristics of tumor cells, it is now generally acknowledged that stromal changes are required for the establishment of cancer. In the present article, we discuss three recent publications that highlight the complex role the stroma has during the development of cancer and the potential for targeting the stroma by therapeutic approaches.

MeSH Terms
Animals Breast Neoplasms/physiopathology Cell Communication Cell Transformation, Neoplastic Epithelial Cells/physiology Female Humans Mammary Glands, Animal/growth & development Mammary Glands, Human/growth & development Mice Signal Transduction Stromal Cells/physiology Transforming Growth Factor beta/physiology
Chemicals
Transforming Growth Factor beta
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Barcellos-Hoff Mary Helen
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA. [email protected]
Medina Daniel
References (40)
40 references, click to expand
  1. The potential influence of radiation-induced microenvironments in neoplastic progression.
    J Mammary Gland Biol Neoplasia. 1998 Apr;3(2):165-75 PMID: 10819525
  2. Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells.
    Cancer Res. 2000 Mar 1;60(5):1254-60 PMID: 10728684
  3. Inflammatory cells and cancer: think different!
    J Exp Med. 2001 Mar 19;193(6):F23-6 PMID: 11257144
  4. Cancer: looking outside the genome.
    Nat Rev Mol Cell Biol. 2000 Oct;1(1):76-9 PMID: 11413493
  5. It takes a tissue to make a tumor: epigenetics, cancer and the microenvironment.
    J Mammary Gland Biol Neoplasia. 2001 Apr;6(2):213-21 PMID: 11501581
  6. TGF-beta signaling in tumor suppression and cancer progression.
    Nat Genet. 2001 Oct;29(2):117-29 PMID: 11586292
  7. Phenotypic and genetic alterations in mammary stroma: implications for tumour progression.
    Breast Cancer Res. 2001;3(6):373-9 PMID: 11737888
  8. TGF-beta signaling: positive and negative effects on tumorigenesis.
    Curr Opin Genet Dev. 2002 Feb;12(1):22-9 PMID: 11790550
  9. Putting tumours in context.
    Nat Rev Cancer. 2001 Oct;1(1):46-54 PMID: 11900251
  10. Stromal effects on mammary gland development and breast cancer.
    Science. 2002 May 10;296(5570):1046-9 PMID: 12004111
  11. Latent transforming growth factor-beta activation in mammary gland: regulation by ovarian hormones affects ductal and alveolar proliferation.
    Am J Pathol. 2002 Jun;160(6):2081-93 PMID: 12057913
  12. Clinical translation of angiogenesis inhibitors.
    Nat Rev Cancer. 2002 Oct;2(10):727-39 PMID: 12360276
  13. A novel method for growing human breast epithelium in vivo using mouse and human mammary fibroblasts.
    Endocrinology. 2002 Dec;143(12):4886-96 PMID: 12446616
  14. The not-so innocent bystander: the microenvironment as a therapeutic target in cancer.
    Expert Opin Ther Targets. 2003 Feb;7(1):71-88 PMID: 12556204
  15. Targeting the TGF beta signaling network in human neoplasia.
    Cancer Cell. 2003 Jun;3(6):531-6 PMID: 12842082
  16. Ets2-dependent stromal regulation of mouse mammary tumors.
    Mol Cell Biol. 2003 Dec;23(23):8614-25 PMID: 14612405
  17. TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia.
    Science. 2004 Feb 6;303(5659):848-51 PMID: 14764882
  18. The stroma as a crucial target in rat mammary gland carcinogenesis.
    J Cell Sci. 2004 Mar 15;117(Pt 8):1495-502 PMID: 14996910
  19. Reconstruction of functionally normal and malignant human breast tissues in mice.
    Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):4966-71 PMID: 15051869
  20. Exogenous TGF-beta1 promotes stromal development in the heifer mammary gland.
    J Dairy Sci. 2004 Apr;87(4):896-904 PMID: 15259224
  21. Carcinoma and stromal enzyme activity profiles associated with breast tumor growth in vivo.
    Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13756-61 PMID: 15356343
  22. Breast cancer: induction of differentiation by embryonic tissue.
    Science. 1973 Sep 14;181(4104):1057-8 PMID: 4269415
  23. Intrauterine transplantation of rat basal cell carcinoma as a model for reconversion of malignant to benign growth.
    Cancer Res. 1977 Aug;37(8 Pt 1):2544-52 PMID: 872081
  24. Enhancement of the tumorigenicity of preneoplastic mammary nodule lines by enzymatic dissociation.
    J Natl Cancer Inst. 1978 May;60(5):1121-6 PMID: 205661
  25. Detection of inapparent nodule-transformed cells in the mammary gland tissues of virgin female BALB/cfC3H mice.
    Cancer Res. 1978 Jul;38(7):2103-11 PMID: 207423
  26. The induction of adenocarcinomatous differentiation in neoplastic bladder epithelium by an embryonic prostatic inductor.
    J Urol. 1982 Oct;128(4):858-61 PMID: 7143620
  27. The multistep nature of cancer development.
    Cancer Res. 1984 Oct;44(10):4217-23 PMID: 6467183
  28. Pre-cancerous steps in carcinogenesis. Their physiological adaptive nature.
    Biochim Biophys Acta. 1984;738(4):171-80 PMID: 6394048
  29. Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing.
    N Engl J Med. 1986 Dec 25;315(26):1650-9 PMID: 3537791
  30. Reversible inhibition of mammary gland growth by transforming growth factor-beta.
    Science. 1987 Jul 17;237(4812):291-3 PMID: 3474783
  31. Stromal involvement in malignant growth.
    Adv Cancer Res. 1988;50:159-96 PMID: 3287842
  32. A clonal derivative of mammary epithelial cell line COMMA-D retains stem cell characteristics of unique morphological and functional heterogeneity.
    Exp Cell Res. 1988 Jul;177(1):109-21 PMID: 2455648
  33. The influence of extracellular matrix on gene expression: is structure the message?
    J Cell Sci Suppl. 1987;8:327-43 PMID: 3332665
  34. Regulation of mammary growth and function by TGF-beta.
    Mol Reprod Dev. 1992 Jun;32(2):145-51 PMID: 1637552
  35. Transforming growth factor-beta activation in irradiated murine mammary gland.
    J Clin Invest. 1994 Feb;93(2):892-9 PMID: 8113421
  36. Evidence that carcinogenesis involves an imbalance between epigenetic high-frequency initiation and suppression of promotion.
    Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1332-6 PMID: 7877977
  37. Cell-adhesion-dependent influences on genomic instability and carcinogenesis.
    Curr Opin Cell Biol. 1998 Oct;10(5):647-53 PMID: 9818176
  38. Overexpression of a kinase-deficient transforming growth factor-beta type II receptor in mouse mammary stroma results in increased epithelial branching.
    Mol Biol Cell. 1999 Apr;10(4):1221-34 PMID: 10198068
  39. Stroma is not a major target in DMBA-mediated tumorigenesis of mouse mammary preneoplasia.
    J Cell Sci. 2005 Jan 1;118(Pt 1):123-7 PMID: 15585572
  40. Transforming growth factor-beta and breast cancer: Mammary gland development.
    Breast Cancer Res. 2000;2(2):92-9 PMID: 11250698
Article Info
Journal
Breast cancer research : BCR
Abbr.
Breast Cancer Res
ISSN
1465-542X
DOI
10.1186/bcr972
Email
[email protected]
Published
2005-00-00
Epub
2004-00-25
Pages
33-6
Language
English
Region
England
NLM ID
100927353
PMCID
PMC1064117
Subset
IM
Grants
NIEHS NIH HHS · U01 ES012801 · United States
External Links
PubMed source DOI: 10.1186/bcr972 PMC Full Text View journal details
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