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PMID: 15728239 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Ets-1, a functional cofactor of T-bet, is essential for Th1 inflammatory responses.

The Journal of experimental medicine ·Vol. 201 ·No. 4 ·2005-02-21 ·Pages 615-26

Grenningloh R, Kang BY, Ho IC

Abstract

To mount an effective type 1 immune response, type 1 T helper (Th1) cells must produce inflammatory cytokines and simultaneously suppress the expression of antiinflammatory cytokines. How these two processes are coordinately regulated at the molecular level is still unclear. In this paper, we show that the proto-oncogene E26 transformation-specific-1 (Ets-1) is necessary for T-bet to promote interferon-gamma production and that Ets-1 is essential for mounting effective Th1 inflammatory responses in vivo. In addition, Ets-1-deficient Th1 cells also produce a very high level of interleukin 10. Thus, Ets-1 plays a crucial and unique role in the reciprocal regulation of inflammatory and antiinflammatory Th responses.

MeSH Terms
Animals Cell Proliferation Colitis/metabolism Cytokines/metabolism Female Inflammation/immunology Mice Mice, Knockout Mice, SCID Proto-Oncogene Protein c-ets-1 Proto-Oncogene Proteins/deficiency,genetics,metabolism Proto-Oncogene Proteins c-ets T-Box Domain Proteins Th1 Cells/immunology,metabolism Transcription Factors/deficiency,genetics,metabolism
Chemicals
Cytokines Ets1 protein, mouse Proto-Oncogene Protein c-ets-1 Proto-Oncogene Proteins Proto-Oncogene Proteins c-ets T-Box Domain Proteins T-box transcription factor TBX21 Transcription Factors
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Grenningloh Roland
Department of Medicine, Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA.
Kang Bok Yun
Ho I-Cheng
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.20041330
Published
2005-02-21
Pages
615-26
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2213045
Subset
IM
Grants
NIAID NIH HHS · R01 AI054451 · United States
NIAID NIH HHS · R01 AI054451-01 · United States
External Links
PubMed source DOI: 10.1084/jem.20041330 PMC Full Text View journal details
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