Abnormal development of the thymus in "nude" mice.
Nude mice bearing grafts of normal thymus reject skin grafts and have low, but higher than usual, lymphocyte counts. Nude bone marrow can successfully repopulate the thymus and thymus-derived areas of lethelly irradiated recipient mice. Attempts to reconstitute nude mice with normal fetal liver failed. The so-called thymic rudiment of nude mice when grafted to normal mice did not develop thymocytes. These experiments show that nude mice suffer from a defect of the epithelial portion of the thymus rather than of the precursors of thymocytes.
12 references, click to expand
-
'Nude', a new hairless gene with pleiotropic effects in the mouse.Genet Res. 1966 Dec;8(3):295-309 PMID: 5980117
-
Absence of thymus in a mouse mutant.Nature. 1968 Jan 27;217(5126):370-1 PMID: 5639157
-
Tissue interaction in the development of thymus lymphocytes.J Exp Med. 1969 Feb 1;129(2):431-42 PMID: 5762051
-
The lymphoid tissues in mice with congenital aplasia of the thymus.Clin Exp Immunol. 1969 Jun;4(6):637-44 PMID: 5784127
-
Thymus dependence of theta-bearing cells in the peripheral lymphoid tissues of mice.Immunology. 1970 Jun;18(6):931-42 PMID: 5428870
-
Cytological identification of radiation-chimaeras.Nature. 1956 Mar 10;177(4506):452-4 PMID: 13309336
-
Observations on the immunobiology of 'nude' mice.Immunology. 1971 Feb;20(2):247-52 PMID: 4100989
-
Studies on the differentiation of thymus-derived lymphocytes.J Exp Med. 1970 Dec 1;132(6):1216-32 PMID: 5511571
-
Immunological responses of 'nude' mice.Clin Exp Immunol. 1971 Feb;8(2):305-17 PMID: 4929778
-
Immunologic complementation between thymus and marrow cells--a model for the two-cell theory of immunocompetence.Transplant Rev. 1969;1:92-113 PMID: 4945477
-
Chromosome preparation from fresh and cultured tissues using a modification of the drying technique.Nature. 1961 Dec 23;192:1213-4 PMID: 13894382
-
Thymus dysgenesis in nude (nu nu) mice.J Embryol Exp Morphol. 1970 Nov;24(3):615-23 PMID: 5493276
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: [email protected]
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
