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PMID: 15826910 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Composition bias and genome polarity of RNA viruses.

Virus research ·Vol. 109 ·No. 1 ·2005-04-00 ·Pages 33-7

Auewarakul P

Abstract

I have observed a relationship between GC content in coding sequences of RNA viruses and their genome polarity. Positive-stranded RNA viruses have significantly higher GC contents than negative-stranded RNA viruses. Coding sequences of all negative-stranded RNA viruses are biased toward high A in coding strands (high T in genomes), while two distinct patterns were observed among positive-stranded RNA genomes. This finding suggests that RNA viruses with different genome polarity are under different mutational pressure, which may be a consequence of the difference in the strategies of viral genome expression and replication. The GC content directly affects the viral codon adaptation index using highly expressed human genes as the reference set, which may theoretically predict the efficiency of viral gene expression in human cells.

MeSH Terms
Base Composition Gene Expression Regulation, Viral Genes, Viral Genome, Viral Mutation/genetics,physiology RNA Viruses/genetics,physiology RNA, Viral/chemistry,genetics Selection, Genetic Viral Structural Proteins/genetics Virus Replication/genetics
Chemicals
RNA, Viral Viral Structural Proteins
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Auewarakul Prasert
Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand. [email protected]
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Article Info
Journal
Virus research
Abbr.
Virus Res
ISSN
0168-1702
DOI
10.1016/j.virusres.2004.10.004
Email
[email protected]
Published
2005-04-00
Epub
2004-00-18
Pages
33-7
Language
English
Region
Netherlands
NLM ID
8410979
PMCID
PMC7114242
Subset
IM
External Links
PubMed source DOI: 10.1016/j.virusres.2004.10.004 PMC Full Text View journal details
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