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PMID: 15864338 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Inflammation, stress, and diabetes.

The Journal of clinical investigation ·Vol. 115 ·No. 5 ·2005-05-00 ·Pages 1111-9

Wellen KE, Hotamisligil GS

Abstract

Over the last decade, an abundance of evidence has emerged demonstrating a close link between metabolism and immunity. It is now clear that obesity is associated with a state of chronic low-level inflammation. In this article, we discuss the molecular and cellular underpinnings of obesity-induced inflammation and the signaling pathways at the intersection of metabolism and inflammation that contribute to diabetes. We also consider mechanisms through which the inflammatory response may be initiated and discuss the reasons for the inflammatory response in obesity. We put forth for consideration some hypotheses regarding important unanswered questions in the field and suggest a model for the integration of inflammatory and metabolic pathways in metabolic disease.

MeSH Terms
Adipocytes/immunology,metabolism Animals Diabetes Mellitus/immunology,metabolism Humans Inflammation/immunology,metabolism Insulin Resistance/immunology,physiology Macrophages/immunology,metabolism Obesity/immunology,metabolism Stress, Physiological/immunology,metabolism
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Wellen Kathryn E
Department of Genetics & Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
Hotamisligil Gökhan S
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI25102
Published
2005-05-00
Pages
1111-9
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC1087185
Subset
IM
External Links
PubMed source DOI: 10.1172/JCI25102 PMC Full Text View journal details
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