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PMID: 15976025 Published · ppublish English Comparative Study Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, P.H.S.

The evolution of vertebrate Toll-like receptors.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 102 ·No. 27 ·2005-07-05 ·Pages 9577-82

Roach JC, Glusman G, Rowen L, Kaur A, Purcell MK, Smith KD, Hood LE, Aderem A

Abstract

The complete sequences of Takifugu Toll-like receptor (TLR) loci and gene predictions from many draft genomes enable comprehensive molecular phylogenetic analysis. Strong selective pressure for recognition of and response to pathogen-associated molecular patterns has maintained a largely unchanging TLR recognition in all vertebrates. There are six major families of vertebrate TLRs. This repertoire is distinct from that of invertebrates. TLRs within a family recognize a general class of pathogen-associated molecular patterns. Most vertebrates have exactly one gene ortholog for each TLR family. The family including TLR1 has more species-specific adaptations than other families. A major family including TLR11 is represented in humans only by a pseudogene. Coincidental evolution plays a minor role in TLR evolution. The sequencing phase of this study produced finished genomic sequences for the 12 Takifugu rubripes TLRs. In addition, we have produced >70 gene models, including sequences from the opossum, chicken, frog, dog, sea urchin, and sea squirt.

MeSH Terms
Animals Base Sequence Computational Biology/methods Evolution, Molecular Gene Components Genomics/methods Membrane Glycoproteins/genetics Models, Genetic Molecular Sequence Data Multigene Family/genetics Phylogeny Receptors, Cell Surface/genetics Sequence Analysis, DNA Species Specificity Takifugu/genetics Toll-Like Receptor 1 Toll-Like Receptors Vertebrates/genetics
Chemicals
Membrane Glycoproteins Receptors, Cell Surface Toll-Like Receptor 1 Toll-Like Receptors
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Roach Jared C
Institute for Systems Biology, Seattle, WA 98103, USA. [email protected]
Glusman Gustavo
Rowen Lee
Kaur Amardeep
Purcell Maureen K
Smith Kelly D
Hood Leroy E
Aderem Alan
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.0502272102
Email
[email protected]
Published
2005-07-05
Epub
2005-00-23
Pages
9577-82
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC1172252
Subset
IM
Grants
NIAID NIH HHS · K08 AI056092 · United States
NIAID NIH HHS · 5K08AI056092 · United States
Databases
GENBANK
AC156430, AC156431, AC156432, AC156433, AC156434, AC156435, AC156436, AC156437, AC156438, AC156439, AC156440
External Links
PubMed source DOI: 10.1073/pnas.0502272102 PMC Full Text View journal details
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