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PMID: 1598911 Published · ppublish English Journal Article

Segregation analysis detects a major gene controlling blood infection levels in human malaria.

American journal of human genetics ·Vol. 50 ·No. 6 ·1992-06-00 ·Pages 1308-17

Abel L, Cot M, Mulder L, Carnevale P, Feingold J

Abstract

The profound influence that the genetic makeup of the host has on resistance to malaria infection has been established in numerous animal studies. This genetic heterogeneity is one of the main causes of the difficulties in developing an effective malaria vaccine. Segregation analysis is the first step in identifying the nature of genetic factors involved in the expression of human complex diseases, as infectious diseases. To assess the role of host genes in human malaria, we performed segregation analysis of blood parasite densities in 42 Cameroonian families by using both the unified mixed model and the class D regressive model of analysis. The results provide clear evidence for the presence of a recessive major gene controlling the degree of infection in human malaria. Parameter estimates show a frequency of .44-.48 for the deleterious allele, indicating that about 21% of the population is predisposed to high levels of infection.

MeSH Terms
Adolescent Adult Age Factors Alleles Analysis of Variance Animals Child Child, Preschool Female Genes, Recessive Genetic Predisposition to Disease Humans Infant Malaria/blood,genetics Malaria, Falciparum/blood,genetics Male Middle Aged Pedigree Plasmodium falciparum/isolation & purification Regression Analysis Seasons
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Abel L
INSERM Unité 194, Hôpital Pitié-Salpêtrière, Paris, France.
Cot M
Mulder L
Carnevale P
Feingold J
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Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
Published
1992-06-00
Pages
1308-17
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC1682575
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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