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PMID: 16177317 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Effects of repeated Chlamydia pneumoniae inoculations on aortic lipid accumulation and inflammatory response in C57BL/6J mice.

Infection and immunity ·Vol. 73 ·No. 10 ·2005-10-00 ·Pages 6458-66

Törmäkangas L, Erkkilä L, Korhonen T, Tiirola T, Bloigu A, Saikku P, Leinonen M

Abstract

Chlamydia pneumoniae is a common respiratory tract pathogen, and persistent infections have been associated with atherosclerosis. We studied the effects of repeated chlamydial inoculations on the inflammatory response and on aortic lipid accumulation in C57BL/6J mice. Mice fed a diet supplemented with 0.2% cholesterol were infected three or six times with C. pneumoniae every fourth week. Sera and lungs were analyzed for inflammatory responses, lung tissues were tested for the presence of C. pneumoniae DNA and RNA, and intimal lipid accumulation in the aortic sinus was quantified. High levels of chlamydial heat shock protein 60 (Hsp60) immunoglobulin G2c subclass antibodies were detected in all of the infected mice, and a positive and statistically significant correlation was found between these antibodies and autoantibodies against mouse Hsp60. Both Hsp60 antibody levels correlated with the severity of lung tissue inflammation. The cholesterol supplement in the diet had no effect on serum cholesterol levels. Significantly larger intimal lipid lesions were seen in the mouse group infected six times (6,542 mum(2)) than in the control group (1,376 mum(2); P = 0.034). In conclusion, repeated inoculations increased aortic sinus lipid accumulation in normocholesterolemic mice. The correlation between the antibodies to mouse and chlamydial Hsp60 proteins and their association with lung inflammation further support the theory of the development of an autoimmune response against heat shock proteins after repeated chlamydial infections.

MeSH Terms
Animals Antibodies, Bacterial/blood Arteriosclerosis/etiology,metabolism,microbiology Chaperonin 60/immunology Chlamydophila Infections/immunology,metabolism,microbiology Chlamydophila pneumoniae/pathogenicity Cholesterol/blood Cholesterol, Dietary/administration & dosage DNA, Bacterial/analysis Female Lipid Metabolism Lipids/analysis Lung/chemistry,pathology Mice Mice, Inbred C57BL Pneumonia, Bacterial/metabolism,microbiology RNA, Bacterial/analysis Sinus of Valsalva/chemistry,metabolism,pathology Triglycerides/blood
Chemicals
Antibodies, Bacterial Chaperonin 60 Cholesterol, Dietary DNA, Bacterial Lipids RNA, Bacterial Triglycerides Cholesterol
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Törmäkangas Liisa
National Public Health Institute, Oulu, Finland. [email protected]
Erkkilä Leena
Korhonen Taina
Tiirola Terttu
Bloigu Aini
Saikku Pekka
Leinonen Maija
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
Published
2005-10-00
Pages
6458-66
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC1230915
Subset
IM
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