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PMID: 16256003 Published · ppublish English Comparative Study Journal Article Review

Influence of dietary carbohydrate and fat on LDL and HDL particle distributions.

Current atherosclerosis reports ·Vol. 7 ·No. 6 ·2005-11-00 ·Pages 455-9

Siri PW, Krauss RM

Abstract

Variations in the size and density distributions of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particles have been related to risk for cardiovascular disease. In particular, increased levels of small, dense LDL particles, together with reduced levels of large HDL and increases in small HDL, are integral features of the atherogenic dyslipidemia found in patients with insulin resistance, obesity, and metabolic syndrome. Increased dietary carbohydrates, particularly simple sugars and starches with high glycemic index, can increase levels of small, dense LDL and HDL, primarily by mechanisms that involve increasing plasma triglyceride concentrations. Low-carbohydrate diets may have the opposite effects. Diets with differing fatty acid composition can also influence LDL and HDL particle distributions.

MeSH Terms
Cholesterol, HDL/analysis,metabolism Cholesterol, LDL/analysis,metabolism Dietary Carbohydrates/administration & dosage,adverse effects Dietary Fats/administration & dosage,adverse effects Female Humans Hyperlipidemias/prevention & control Male Particle Size Risk Assessment Sensitivity and Specificity
Chemicals
Cholesterol, HDL Cholesterol, LDL Dietary Carbohydrates Dietary Fats
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Siri Patty W
Department of Atherosclerosis Research, Children's Hospital Oakland Research Institute, Oakland, CA 94609, USA.
Krauss Ronald M
References (68)
68 references, click to expand
  1. Comparison of effects of palmitic and stearic acids in the diet on serum cholesterol in man.
    Am J Clin Nutr. 1970 Sep;23(9):1184-93 PMID: 5450836
  2. Short-term consumption of a low-fat diet beneficially affects plasma lipid concentrations only when accompanied by weight loss. Hypercholesterolemia, low-fat diet, and plasma lipids.
    Arterioscler Thromb. 1994 Nov;14(11):1751-60 PMID: 7947600
  3. Susceptibility of small, dense, low-density lipoproteins to oxidative modification in subjects with the atherogenic lipoprotein phenotype, pattern B.
    Am J Med. 1993 Apr;94(4):350-6 PMID: 8475928
  4. Differences in LDL subspecies involve alterations in lipid composition and conformational changes in apolipoprotein B.
    J Lipid Res. 1996 Sep;37(9):1924-35 PMID: 8895058
  5. Characterization of human high-density lipoproteins by gradient gel electrophoresis.
    Biochim Biophys Acta. 1981 Sep 24;665(3):408-19 PMID: 7295744
  6. Mechanisms of HDL lowering in insulin resistant, hypertriglyceridemic states: the combined effect of HDL triglyceride enrichment and elevated hepatic lipase activity.
    Clin Biochem. 2003 Sep;36(6):421-9 PMID: 12951168
  7. Effects of different forms of dietary hydrogenated fats on serum lipoprotein cholesterol levels.
    N Engl J Med. 1999 Jun 24;340(25):1933-40 PMID: 10379016
  8. Effects of a low-fat, high-carbohydrate diet on VLDL-triglyceride assembly, production, and clearance.
    J Clin Invest. 1999 Oct;104(8):1087-96 PMID: 10525047
  9. Dietary fatty acids and the regulation of plasma low density lipoprotein cholesterol concentrations.
    J Nutr. 1998 Feb;128(2 Suppl):444S-448S PMID: 9478045
  10. Effects of National Cholesterol Education Program Step 2 diets relatively high or relatively low in fish-derived fatty acids on plasma lipoproteins in middle-aged and elderly subjects.
    Am J Clin Nutr. 1996 Feb;63(2):234-41 PMID: 8561065
  11. Quantitative effects of dietary fat on serum cholesterol in man.
    Am J Clin Nutr. 1965 Nov;17(5):281-95 PMID: 5846902
  12. Hold the antioxidants and improve plasma lipids?
    J Clin Invest. 2004 May;113(9):1253-5 PMID: 15124014
  13. Elevated high density lipoprotein cholesterol levels correlate with decreased apolipoprotein A-I and A-II fractional catabolic rate in women.
    J Clin Invest. 1989 Jul;84(1):262-9 PMID: 2500457
  14. Carbohydrate-induced hypertriacylglycerolemia: historical perspective and review of biological mechanisms.
    Am J Clin Nutr. 2000 Feb;71(2):412-33 PMID: 10648253
  15. Differences in carbohydrate content of low density lipoproteins associated with low density lipoprotein subclass patterns.
    J Lipid Res. 1990 Sep;31(9):1577-88 PMID: 2246611
  16. Metabolic origins and clinical significance of LDL heterogeneity.
    J Lipid Res. 2002 Sep;43(9):1363-79 PMID: 12235168
  17. Atherogenic lipoprotein phenotype. A proposed genetic marker for coronary heart disease risk.
    Circulation. 1990 Aug;82(2):495-506 PMID: 2372896
  18. Increased apo A-I and apo A-II fractional catabolic rate in patients with low high density lipoprotein-cholesterol levels with or without hypertriglyceridemia.
    J Clin Invest. 1991 Feb;87(2):536-44 PMID: 1899429
  19. Role of triglyceride-rich lipoproteins and hepatic lipase in determining the particle size and composition of high density lipoproteins.
    J Lipid Res. 1986 Dec;27(12):1265-77 PMID: 3559390
  20. Trans fatty acids and coronary heart disease.
    N Engl J Med. 1999 Jun 24;340(25):1994-8 PMID: 10379026
  21. Low-density lipoprotein subclass patterns and lipoprotein response to a reduced-fat diet in men.
    FASEB J. 1994 Jan;8(1):121-6 PMID: 8299884
  22. Individual variability in lipoprotein cholesterol response to National Cholesterol Education Program Step 2 diets.
    Am J Clin Nutr. 1997 Mar;65(3):823-30 PMID: 9062535
  23. Small LDL, atherogenic dyslipidemia, and the metabolic syndrome.
    Circulation. 1997 Jan 7;95(1):1-4 PMID: 8994405
  24. Apolipoprotein B-100 conformation and particle surface charge in human LDL subspecies: implication for LDL receptor interaction.
    Biochemistry. 1998 Sep 15;37(37):12867-74 PMID: 9737865
  25. Omega-3 fatty acids alter lipoprotein subfraction distributions and the in vitro conversion of very low density lipoproteins to low density lipoproteins.
    J Nutr Biochem. 1999 Mar;10(3):151-8 PMID: 15539283
  26. Human HDL cholesterol levels are determined by apoA-I fractional catabolic rate, which correlates inversely with estimates of HDL particle size. Effects of gender, hepatic and lipoprotein lipases, triglyceride and insulin levels, and body fat distribution.
    Arterioscler Thromb. 1994 May;14(5):707-20 PMID: 8172849
  27. High-density lipoprotein apolipoprotein A-I kinetics in obesity.
    Obes Res. 2005 Jun;13(6):1008-16 PMID: 15976143
  28. Effects of dietary fat on high-density-lipoprotein subclasses are influenced by both apolipoprotein E isoforms and low-density-lipoprotein subclass patterns.
    Am J Clin Nutr. 1995 Jun;61(6):1234-40 PMID: 7762523
  29. Effects of fish oil fatty acids on low density lipoprotein size, oxidizability, and uptake by macrophages.
    J Lipid Res. 1995 Mar;36(3):473-84 PMID: 7775859
  30. Influence of glycemic load on HDL cholesterol in youth.
    Am J Clin Nutr. 2005 Feb;81(2):376-9 PMID: 15699224
  31. Comparison of a high-carbohydrate diet with a high-monounsaturated-fat diet in patients with non-insulin-dependent diabetes mellitus.
    N Engl J Med. 1988 Sep 29;319(13):829-34 PMID: 3045553
  32. Nuclear magnetic resonance lipoprotein abnormalities in prediabetic subjects in the Insulin Resistance Atherosclerosis Study.
    Circulation. 2005 Jun 28;111(25):3465-72 PMID: 15983261
  33. The genetics of serum lipid responsiveness to dietary interventions.
    Proc Nutr Soc. 1999 Feb;58(1):171-87 PMID: 10343355
  34. Dietary long-chain n-3 PUFAs increase LPL gene expression in adipose tissue of subjects with an atherogenic lipoprotein phenotype.
    J Lipid Res. 2002 Jun;43(6):979-85 PMID: 12032174
  35. Effects of fats and fatty acids on blood lipids in humans: an overview.
    Am J Clin Nutr. 1994 Dec;60(6 Suppl):1017S-1022S PMID: 7977143
  36. Plasma lipoprotein lipid and Lp[a] changes with substitution of elaidic acid for oleic acid in the diet.
    J Lipid Res. 1992 Jul;33(7):1029-36 PMID: 1431582
  37. Effect of a low-glycaemic index--low-fat--high protein diet on the atherogenic metabolic risk profile of abdominally obese men.
    Br J Nutr. 2001 Nov;86(5):557-68 PMID: 11737954
  38. Effects of nonstatin lipid drug therapy on high-density lipoprotein metabolism.
    Am J Cardiol. 2003 Apr 3;91(7A):18E-23E PMID: 12679199
  39. An omega-3 polyunsaturated fatty acid concentrate increases plasma high-density lipoprotein 2 cholesterol and paraoxonase levels in patients with familial combined hyperlipidemia.
    Metabolism. 2004 Feb;53(2):153-8 PMID: 14767865
  40. Insulin resistance and hyperinsulinemia in individuals with small, dense low density lipoprotein particles.
    J Clin Invest. 1993 Jul;92(1):141-6 PMID: 8325978
  41. Effect of different forms of dietary hydrogenated fats on LDL particle size.
    Am J Clin Nutr. 2003 Sep;78(3):370-5 PMID: 12936917
  42. Effects of monounsaturated enriched sunflower oil on CHD risk factors including LDL size and copper-induced LDL oxidation.
    J Am Coll Nutr. 2001 Aug;20(4):320-6 PMID: 11506059
  43. New insights into the regulation of HDL metabolism and reverse cholesterol transport.
    Circ Res. 2005 Jun 24;96(12 ):1221-32 PMID: 15976321
  44. Discrete subspecies of human low density lipoproteins are heterogeneous in their interaction with the cellular LDL receptor.
    J Lipid Res. 1991 Nov;32(11):1741-53 PMID: 1770294
  45. Diets high and low in glycemic index versus high monounsaturated fat diets: effects on glucose and lipid metabolism in NIDDM.
    Eur J Clin Nutr. 1999 Jun;53(6):473-8 PMID: 10403584
  46. Reduced HDL particle size as an additional feature of the atherogenic dyslipidemia of abdominal obesity.
    J Lipid Res. 2001 Dec;42(12):2007-14 PMID: 11734573
  47. Change in LDL particle size is associated with change in plasma triglyceride concentration.
    Arterioscler Thromb. 1992 Nov;12(11):1284-90 PMID: 1420088
  48. Effects of dietary saturated, monounsaturated and n-3 fatty acids on fasting lipoproteins, LDL size and post-prandial lipid metabolism in healthy subjects.
    Atherosclerosis. 2003 Mar;167(1):149-58 PMID: 12618280
  49. Nutrient intake comparisons between Framingham and rural and Urban Puriscal, Costa Rica. Associations with lipoproteins, apolipoproteins, and low density lipoprotein particle size.
    Arterioscler Thromb. 1991 Jul-Aug;11(4):1089-99 PMID: 2065030
  50. Changes in plasma lipoproteins during low-fat, high-carbohydrate diets: effects of energy intake.
    Am J Clin Nutr. 2000 Jun;71(6):1439-47 PMID: 10837283
  51. A low-fat diet decreases high density lipoprotein (HDL) cholesterol levels by decreasing HDL apolipoprotein transport rates.
    J Clin Invest. 1990 Jan;85(1):144-51 PMID: 2104877
  52. n-3 fatty acids and lipoproteins: comparison of results from human and animal studies.
    Lipids. 1996 Mar;31(3):243-52 PMID: 8900453
  53. Relationship between carbohydrate-induced hypertriglyceridemia and fatty acid synthesis in lean and obese subjects.
    J Lipid Res. 2000 Apr;41(4):595-604 PMID: 10744780
  54. Changes in LDL particle composition after the consumption of meals containing different amounts and types of fat.
    Am J Clin Nutr. 2002 Aug;76(2):345-50 PMID: 12145005
  55. Effect of dietary fatty acids on serum lipids and lipoproteins. A meta-analysis of 27 trials.
    Arterioscler Thromb. 1992 Aug;12(8):911-9 PMID: 1386252
  56. Dietary and genetic effects on low-density lipoprotein heterogeneity.
    Annu Rev Nutr. 2001;21:283-95 PMID: 11375438
  57. Low-density-lipoprotein subclasses and response to a low-fat diet in healthy men.
    Am J Clin Nutr. 1995 Aug;62(2):478S-487S PMID: 7625363
  58. Change in dietary saturated fat intake is correlated with change in mass of large low-density-lipoprotein particles in men.
    Am J Clin Nutr. 1998 May;67(5):828-36 PMID: 9583838
  59. Effects of omega-3 fatty acid supplementation and exercise on low-density lipoprotein and high-density lipoprotein subfractions.
    Metabolism. 2004 Jun;53(6):749-54 PMID: 15164323
  60. LDL subclass patterns and lipoprotein response to a low-fat, high-carbohydrate diet in women.
    Arterioscler Thromb Vasc Biol. 1997 Apr;17(4):707-14 PMID: 9108784
  61. Body weight and low-density lipoprotein cholesterol changes after consumption of a low-fat ad libitum diet.
    JAMA. 1995 Nov 8;274(18):1450-5 PMID: 7474191
  62. Effect of gender, age, and lipid status on low density lipoprotein subfraction distribution. Results from the Framingham Offspring Study.
    Arteriosclerosis. 1987 Sep-Oct;7(5):483-90 PMID: 3675308
  63. Glycemic load and chronic disease.
    Nutr Rev. 2003 May;61(5 Pt 2):S49-55 PMID: 12828192
  64. Coordinate changes in levels of human serum low and high density lipoprotein subclasses in healthy men.
    Arteriosclerosis. 1988 Mar-Apr;8(2):155-62 PMID: 3348757
  65. Accumulation of lipoprotein fractions and subfractions in the arterial wall, determined in an in vitro perfusion system.
    Atherosclerosis. 1996 Jun;123(1-2):43-56 PMID: 8782836
  66. The effect of n-3 fatty acids on low density lipoprotein subfractions.
    Lipids. 2001;36 Suppl:S91-7 PMID: 11837999
  67. Intake of trans fatty acids and low-density lipoprotein size in a Costa Rican population.
    Metabolism. 2003 Jun;52(6):693-8 PMID: 12800093
  68. Differences in receptor binding of LDL subfractions.
    Arterioscler Thromb Vasc Biol. 1996 Jun;16(6):794-801 PMID: 8640407
Article Info
Journal
Current atherosclerosis reports
Abbr.
Curr Atheroscler Rep
ISSN
1523-3804
DOI
10.1007/s11883-005-0062-9
Published
2005-11-00
Pages
455-9
Language
English
Region
United States
NLM ID
100897685
Subset
IM
External Links
PubMed source DOI: 10.1007/s11883-005-0062-9 View journal details
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