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PMID: 16309541 Published · ppublish English Journal Article Review

Molecular predictors of clinical outcome in patients with head and neck squamous cell carcinoma.

International journal of experimental pathology ·Vol. 86 ·No. 6 ·2005-12-00 ·Pages 347-63

Thomas GR, Nadiminti H, Regalado J

Abstract

Head and neck squamous cell carcinoma (HNSCC) involves the upper aerodigestive tract and can destroy the structure and function of organs involved in voice, speech, taste, smell and hearing, as well as vital structures necessary for survival. HNSCC has long been a treatment challenge because of the high rate of recurrences and of advanced disease at the time of diagnosis. Molecular identification of tissue biomarkers in diagnostic biopsy specimens may not only identify patients at risk for developing HNSCC but may also select patients that may benefit from more aggressive treatment modalities. Several biomarkers studied to date such as the proteins p53, cyclin D1, p16, Cox-2 enzyme, epidermal growth factor and vascular endothelial growth factor receptors, matrix metalloproteinases and the Fhit marker for genomic instability could be manipulated for the therapeutic benefit of these patients. This review presents the most updated information on molecular biomarkers with the greatest prognostic potential in HNSCC and discusses some factors that contribute to the controversy concerning their prognostic importance.

MeSH Terms
Biomarkers, Tumor/genetics Carcinoma, Squamous Cell/genetics,pathology Gene Expression Profiling Genes, Tumor Suppressor Head and Neck Neoplasms/genetics,pathology Humans Neoplasm Recurrence, Local/genetics Oligonucleotide Array Sequence Analysis Prognosis
Chemicals
Biomarkers, Tumor
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Thomas Giovana R
Department of Otolaryngology-Head and Neck Surgery, University of Miami School of Medicine, Miami, FL 33136, USA. [email protected]
Nadiminti Hari
Regalado Jacinto
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Article Info
Journal
International journal of experimental pathology
Abbr.
Int J Exp Pathol
ISSN
0959-9673
DOI
10.1111/j.0959-9673.2005.00447.x
Email
[email protected]
Published
2005-12-00
Pages
347-63
Language
English
Region
England
NLM ID
9014042
PMCID
PMC2517451
Subset
IM
External Links
PubMed source DOI: 10.1111/j.0959-9673.2005.00447.x PMC Full Text View journal details
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