Malignant transformation of hamster kidney cells by BK virus.

Journal of virology ·Vol. 15 ·No. 2 ·1975-02-00 ·Pages 420-2

Portolani M, Barbanti-Brodano G, Placa ML

Abstract

Primary hamster kidney cells were transformed by BK virus, a new human papovavirus. Transformed (HKBK) cell produced BK virus T antigen and induced tumors in hamsters that developed antibodies to BK virus T antigen. BK virus was rescued from HKBK cells by Sendai virus-assisted fusion with permissive cells. One out of six cell lines derived from HKBK cell-induced tumors showed the same characteristics as HKBK cells.

MeSH Terms

Animals Antibodies, Viral/isolation & purification Antigens, Neoplasm/isolation & purification Antigens, Viral/isolation & purification Cell Fusion Cell Line Cell Transformation, Neoplastic Cricetinae Culture Techniques Fibroblasts Fluorescent Antibody Technique Haplorhini Humans Kidney Neoplasm Transplantation Neoplasms, Experimental/immunology Parainfluenza Virus 1, Human/growth & development Polyomavirus/growth & development,immunology,isolation & purification

Chemicals

Antibodies, Viral Antigens, Neoplasm Antigens, Viral

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Portolani M

Barbanti-Brodano G

Placa M L

References (17)

17 references, click to expand

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Article Info

Journal

Journal of virology

Abbr.

J Virol

ISSN

0022-538X

DOI

10.1128/JVI.15.2.420-422.1975

Published

1975-02-00

Pages

420-2

Language

English

Region

United States

NLM ID

0113724

PMCID

PMC354469

Subset

External Links

PubMed source DOI: 10.1128/JVI.15.2.420-422.1975 PMC Full Text View journal details

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Malignant transformation of hamster kidney cells by BK virus.

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