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PMID: 16341589 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Carnosine protects the brain of rats and Mongolian gerbils against ischemic injury: after-stroke-effect.

Neurochemical research ·Vol. 30 ·No. 10 ·2005-10-00 ·Pages 1283-8

Dobrota D, Fedorova T, Stvolinsky S, Babusikova E, Likavcanova K, Drgova A, Strapkova A, Boldyrev A

Abstract

Carnosine, a specific constituent of excitable tissues of vertebrates, exhibits a significant antioxidant protecting effect on the brain damaged by ischemic-reperfusion injury when it was administered to the animals before ischemic episode. In this study, the therapeutic effect of carnosine was estimated on animals when this drug was administered intraperitoneally (100 mg/kg body weight) after ischemic episode induced by experimental global brain ischemia. Treatment of the animals with carnosine after ischemic episode under long-term (7-14 days) reperfusion demonstrated its pronounced protective effect on neurological symptoms and animal mortality. Carnosine also prevented higher lipid peroxidation of brain membrane structures and increased a resistance of neuronal membranes to the in vitro induced oxidation. Measurements of malonyl dialdehyde (MDA) in brain homogenates showed its increase in the after brain stroke animals and decreased MDA level in the after brain stroke animals treated with carnosine. We concluded that carnosine compensates deficit in antioxidant defense system of brain damaged by ischemic injury. The data presented demonstrate that carnosine is effective in protecting the brain in the post-ischemic period.

MeSH Terms
Animals Antioxidants/therapeutic use Brain Ischemia/drug therapy,metabolism,pathology,physiopathology Carnosine/therapeutic use Gerbillinae Malondialdehyde/metabolism Neuroprotective Agents/therapeutic use Rats Rats, Wistar Survival Rate
Chemicals
Antioxidants Neuroprotective Agents Malondialdehyde Carnosine
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Dobrota Dusan
Department of Medical Biochemistry, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia. [email protected]
Fedorova Tatiana
Stvolinsky Sergey
Babusikova Eva
Likavcanova Katarina
Drgova Anna
Strapkova Adriana
Boldyrev Alexander
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Article Info
Journal
Neurochemical research
Abbr.
Neurochem Res
ISSN
0364-3190
DOI
10.1007/s11064-005-8799-7
Email
[email protected]
Published
2005-10-00
Pages
1283-8
Language
English
Region
United States
NLM ID
7613461
Subset
IM
External Links
PubMed source DOI: 10.1007/s11064-005-8799-7 View journal details
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