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PMID: 16364196 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Animal disease models generated by genetic engineering of polyamine metabolism.

Journal of cellular and molecular medicine ·Vol. 9 ·No. 4 ·2005-00-00 ·Pages 865-82

Jänne J, Alhonen L, Keinänen TA, Pietilä M, Uimari A, Pirinen E, Hyvönen MT, Järvinen A

Abstract

The polyamines putrescine, spermidine and spermine are natural components of all living cells. Although their exact cellular functions are still largely unknown, a constant supply of these compounds is required for mammalian cell proliferation to occur. Studies with animals displaying genetically altered polyamine metabolism have shown that polyamines are intimately involved in the development of diverse tumors, putrescine apparently has specific role in skin physiology and neuroprotection and the higher polyamines spermidine and spermine are required for the maintenance of pancreatic integrity and liver regeneration. In the absence of ongoing polyamine biosynthesis, murine embryogenesis does not proceed beyond the blastocyst stage. The last years have also witnessed the appearance of the first reports linking genetically altered polyamine metabolism to human diseases.

MeSH Terms
Animals Animals, Genetically Modified Disease Models, Animal Female Genetic Engineering/methods Humans Male Mice Mice, Knockout Mice, Transgenic Models, Biological Mutation Neoplasms/genetics,pathology Phenotype Polyamines/chemistry,metabolism Rats
Chemicals
Polyamines
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Jänne Juhani
Department of Biotechnology and Molecular Medicine, AI Virtanen Institute for Molecular Sciences, University of Kuopio, Finland. [email protected]
Alhonen Leena
Keinänen Tuomo A
Pietilä Marko
Uimari Anne
Pirinen Eija
Hyvönen Mervi T
Järvinen Aki
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Article Info
Journal
Journal of cellular and molecular medicine
Abbr.
J Cell Mol Med
ISSN
1582-1838
DOI
10.1111/j.1582-4934.2005.tb00385.x
Email
[email protected]
Published
2005-00-00
Pages
865-82
Language
English
Region
England
NLM ID
101083777
PMCID
PMC6740286
Subset
IM
External Links
PubMed source DOI: 10.1111/j.1582-4934.2005.tb00385.x PMC Full Text View journal details
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