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PMID: 12927050 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Polyamine metabolism and cancer.

Journal of cellular and molecular medicine ·Vol. 7 ·No. 2 ·2003-00-00 ·Pages 113-26

Thomas T, Thomas TJ

Abstract

Polyamines are aliphatic cations present in all cells. In normal cells, polyamine levels are intricately controlled by biosynthetic and catabolic enzymes. The biosynthetic enzymes are ornithine decarboxylase, S-adenosylmethionine decarboxylase, spermidine synthase, and spermine synthase. The catabolic enzymes include spermidine/spermine acetyltransferase, flavin containing polyamine oxidase, copper containing diamine oxidase, and possibly other amine oxidases. Multiple abnormalities in the control of polyamine metabolism and uptake might be responsible for increased levels of polyamines in cancer cells as compared to that of normal cells. This review is designed to look at the current research in polyamine biosynthesis, catabolism, and transport pathways, enumerate the functions of polyamines, and assess the potential for using polyamine metabolism or function as targets for cancer therapy.

MeSH Terms
Acetyltransferases/metabolism Adenosylmethionine Decarboxylase/metabolism Animals Cell Line Humans Neoplasms/metabolism Ornithine Decarboxylase/metabolism Oxidoreductases Acting on CH-NH Group Donors/metabolism Polyamines/metabolism Spermidine Synthase/metabolism Spermine Synthase/metabolism
Chemicals
Polyamines Oxidoreductases Acting on CH-NH Group Donors polyamine oxidase Acetyltransferases diamine N-acetyltransferase Spermidine Synthase Spermine Synthase Ornithine Decarboxylase Adenosylmethionine Decarboxylase
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Thomas Thresia
Department of Environmental & Community Medicine, University of Medicine and Dentistry of New Jersey - Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA. [email protected]
Thomas T J
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Article Info
Journal
Journal of cellular and molecular medicine
Abbr.
J Cell Mol Med
ISSN
1582-1838
DOI
10.1111/j.1582-4934.2003.tb00210.x
Email
[email protected]
Published
2003-00-00
Pages
113-26
Language
English
Region
England
NLM ID
101083777
PMCID
PMC6740079
Subset
IM
Grants
NCI NIH HHS · CA42439 · United States
NCI NIH HHS · CA73058 · United States
NCI NIH HHS · CA80163 · United States
NIEHS NIH HHS · ES05022 · United States
External Links
PubMed source DOI: 10.1111/j.1582-4934.2003.tb00210.x PMC Full Text View journal details
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