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PMID: 163794 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Genital herpesvirus hominis infection in mice. I. Development of an experimental model.

Infection and immunity ·Vol. 11 ·No. 3 ·1975-03-00 ·Pages 476-80

Overall JC, Kern ER, Schlitzer RL, Friedman SB, Glasgow LA

Abstract

Pregnant female mice, after intravaginal inoculation with Herpesvirus hominis (HVH) type 2, developed vaginitis on days 5 to 7 after virus challenge, followed by hunching and hind limb paralysis on days 7 to 9 and death from encephalitis on days 9 to 11. After initial replication in the mucous membranes of the genital tract, virus spread to the spinal cord and ascended to involve the brain. Viremia or replication of H. hominis type 2 in the liver or spleen was not detected. Virus was cleared from vaginal secretions by days 8 to 10 after infection. Pregnant mice were more susceptible to the infection than nonpregnant mice. This experimental infection in female mice provides a model for genital herpesvirus infection and for herpesvirus infection and for herpesvirus encephalitis in which one can evaluate potentially promising antiviral chemotherapeutic agents.

MeSH Terms
Animals Blood/microbiology Brain/microbiology Disease Models, Animal Female Genitalia, Female/microbiology Herpesviridae Infections Liver/microbiology Mice Mucous Membrane/microbiology Pregnancy Simplexvirus/immunology,isolation & purification Spinal Cord/microbiology Spleen/microbiology Vaginitis/etiology Virus Replication
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Overall J C
Kern E R
Schlitzer R L
Friedman S B
Glasgow L A
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33 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.11.3.476-480.1975
Published
1975-03-00
Pages
476-80
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC415089
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.11.3.476-480.1975 PMC Full Text View journal details
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