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PMID: 16380908 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Preferential transmission of paternal alleles at risk genes in attention-deficit/hyperactivity disorder.

American journal of human genetics ·Vol. 77 ·No. 6 ·2005-12-00 ·Pages 958-65

Hawi Z, Segurado R, Conroy J, Sheehan K, Lowe N, Kirley A, Shields D, Fitzgerald M, Gallagher L, Gill M

Abstract

Family, twin, and adoption studies have demonstrated a significant genetic contribution to the etiology of attention-deficit/hyperactivity disorder (ADHD). Pharmacological, neuroimaging, and animal-model findings suggest imbalances in monoaminergic (dopaminergic, serotonergic, and noradrenergic) neurotransmission in ADHD. We have examined monoaminergic candidate genes for possible genetic association with ADHD in the Irish population, focusing particularly on genes of the dopaminergic and serotonergic systems. We have observed that several of these genes are associated with ADHD, including DAT1, DBH, DRD4, DRD5, and 5HT1B. Here, we present what appears to be a systematic overtransmission of paternal alleles at candidate genes associated with ADHD. For the nine genes included in the analysis, the overall odds ratio for paternal transmission was 2, compared with 1.3 for maternal transmission (paternal vs. maternal chi 2=9.6; P=.0019). Transmission to females, from either parent, was significantly stronger than to males. Possible reasons for this preferential transmission include imprinting and ascertainment bias, although results of further analyses show that the latter is unlikely.

MeSH Terms
Alleles Attention Deficit Disorder with Hyperactivity/epidemiology,genetics Chi-Square Distribution Dopamine Plasma Membrane Transport Proteins/genetics Female Genetic Markers Genetic Predisposition to Disease/epidemiology Humans Ireland/epidemiology Linkage Disequilibrium Male Nuclear Family Odds Ratio Receptors, Dopamine D4/genetics Receptors, Dopamine D5/genetics
Chemicals
Dopamine Plasma Membrane Transport Proteins Genetic Markers Receptors, Dopamine D4 Receptors, Dopamine D5
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Hawi Ziarih
Department of Psychiatry and Genetics, Trinity College, Dublin, Ireland. [email protected]
Segurado Ricardo
Conroy Judith
Sheehan Karen
Lowe Naomi
Kirley Aiveen
Shields Denis
Fitzgerald Michael
Gallagher Louise
Gill Michael
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Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
DOI
10.1086/498174
Email
[email protected]
Published
2005-12-00
Epub
2005-00-26
Pages
958-65
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC1285179
Subset
IM
Grants
Wellcome Trust · United Kingdom
Corrections
CommentIn
PMID: 16960815
CommentIn
PMID: 17325714
External Links
PubMed source DOI: 10.1086/498174 PMC Full Text View journal details
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