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PMID: 16387873 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Positive selection can create false hotspots of recombination.

Genetics ·Vol. 172 ·No. 3 ·2006-03-00 ·Pages 2011-4

Reed FA, Tishkoff SA

Abstract

Simulations of positive directional selection, under parameter values appropriate for approximating human genetic diversity and rates of recombination, reveal that the effects of strong selective sweeps on patterns of linkage disequilibrium (LD) mimic the pattern expected with recombinant hotspots.

MeSH Terms
Computer Simulation Humans Linkage Disequilibrium Meiosis/genetics Models, Genetic Recombination, Genetic Selection, Genetic Species Specificity
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Reed Floyd A
Department of Biology, University of Maryland, College Park, Maryland 20742, USA. [email protected]
Tishkoff Sarah A
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Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
0016-6731
DOI
10.1534/genetics.105.052183
Email
[email protected]
Published
2006-03-00
Epub
2005-00-30
Pages
2011-4
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC1456281
Subset
IM
External Links
PubMed source DOI: 10.1534/genetics.105.052183 PMC Full Text View journal details
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