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PMID: 16506092 Published · ppublish English Journal Article Review

Dynamic nucleosomes.

Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology ·Vol. 14 ·No. 1 ·2006-00-00 ·Pages 5-16

Luger K

Abstract

It is now widely recognized that the packaging of genomic DNA together with core histones, linker histones, and other functional proteins into chromatin profoundly influences nuclear processes such as transcription, replication, repair and recombination. How chromatin structure modulates the expression and maintenance of knowledge encoded in eukaryotic genomes, and how these processes take place within the context of a highly complex and compacted genomic chromatin environment remains a major unresolved question in biology. Here we review recent advances in our understanding of how nucleosome and chromatin structure may have to adapt to promote these vital functions.

MeSH Terms
Animals Chromatin/chemistry,metabolism DNA/chemistry,genetics,metabolism DNA Repair DNA Replication Histones/chemistry,metabolism Humans Molecular Chaperones/physiology Nucleosomes/chemistry,metabolism Protein Processing, Post-Translational Protein Structure, Quaternary Recombination, Genetic Transcription, Genetic
Chemicals
Chromatin Histones Molecular Chaperones Nucleosomes DNA
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Luger Karolin
Howard Hughes Medical Institute and Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, 80523-1870, USA. [email protected]
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Article Info
Journal
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology
Abbr.
Chromosome Res
ISSN
0967-3849
DOI
10.1007/s10577-005-1026-1
Email
[email protected]
Published
2006-00-00
Pages
5-16
Language
English
Region
Netherlands
NLM ID
9313452
Subset
IM
External Links
PubMed source DOI: 10.1007/s10577-005-1026-1 View journal details
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