The effect of serotonin (5-hydroxytryptamine) and derivatives on guanosine 3',5'-monophosphate in human monocytes.

The Journal of clinical investigation ·Vol. 55 ·No. 2 ·1975-02-00 ·Pages 431-5

Sandler JA, Clyman RI, Manganiello VC, Vaughan M

Abstract

The effects of several putative mediators of inflammatory responses on the cyclic nucleotide content of mononuclear leukocytes from human peripheral blood were investigated. Incubation of mononuclear cells with 100 muM serotonin (a maximally effective concentration) for 5 min caused a five- to eightfold increase in their content of guanosine 3',5'-monophosphate (cAMP)...

MeSH Terms

Bradykinin/pharmacology Cell Fractionation Cyclic AMP/blood Cyclic GMP/blood Histamine/pharmacology Humans In Vitro Techniques Leukocytes/analysis Melatonin/pharmacology Monocytes/analysis Polystyrenes/pharmacology Serotonin/pharmacology Tryptamines/pharmacology

Chemicals

Polystyrenes Tryptamines Serotonin Histamine Cyclic AMP Cyclic GMP Melatonin Bradykinin

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Sandler J A

Clyman R I

Manganiello V C

Vaughan M

References (12)

12 references, click to expand

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A protein binding assay for adenosine 3':5'-cyclic monophosphate.
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Nat New Biol. 1971 Jan 6;229(1):27-9 PMID: 4322091
The effect of polystyrene beads on cyclic 3',5'-adenosine monophosphate concentration in leukocytes.
J Clin Invest. 1971 Dec;50(12):2741-4 PMID: 4331596
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J Biol Chem. 1972 Feb 25;247(4):1106-13 PMID: 4334491
Guanosine 3':5'-cyclic monophosphate: a possible intracellular mediator of mitogenic influences in lymphocytes.
Proc Natl Acad Sci U S A. 1972 Oct;69(10):3024-7 PMID: 4342973
Cyclic GMP and cell movement.
Nature. 1973 Oct 26;245(5426):458-60 PMID: 4356150
Mechanisms of lysosomal enzyme release from human leukocytes. II. Effects of cAMP and cGMP, autonomic agonists, and agents which affect microtubule function.
J Clin Invest. 1974 Jan;53(1):297-309 PMID: 4357615
Hormonal control of lysosomal enzyme release from human neutrophils. Effects of autonomic agents on enzyme release, phagocytosis, and cylic nucleotide levels.
J Exp Med. 1974 Jun 1;139(6):1395-414 PMID: 4364334
The percentage of monocytes among "mononuclear" cell fractions obtained from normal human blood.
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Article Info

Journal

The Journal of clinical investigation

Abbr.

J Clin Invest

ISSN

0021-9738

DOI

10.1172/JCI107948

Published

1975-02-00

Pages

431-5

Language

English

Region

United States

NLM ID

7802877

PMCID

PMC301763

Subset

External Links

PubMed source DOI: 10.1172/JCI107948 PMC Full Text View journal details

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The effect of serotonin (5-hydroxytryptamine) and derivatives on guanosine 3',5'-monophosphate in human monocytes.

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