Nonencapsulated Variant of Cryptococcus neoformans I. Virulence Studies and Characterization of Soluble Polysaccharide.

Infection and immunity ·Vol. 3 ·No. 2 ·1971-02-00 ·Pages 287-94

Kozel TR, Cazin J

Abstract

A weakly virulent nonencapsulated variant of Cryptococcus neoformans is described. The chemical structure and antigenicity of the soluble polysaccharides produced by the variant strain and a typical virulent strain were compared. The soluble polysaccharides produced by both strains were composed of the same constituent monosaccharides; however, the virulent strain produced a polysaccharide having a greater uronic acid content and a larger molecular size than that of the variant strain. Soluble polysaccharides from the two strains are not closely related immunologically. Soluble polysaccharide obtained from the virulent strain did not affect persistence of the variant strain in mice.

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Kozel T R

Department of Microbiology, University of Iowa, Iowa City, Iowa 52240.

Cazin J

References (16)

16 references, click to expand

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Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.3.2.287-294.1971

Published

1971-02-00

Pages

287-94

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC416145

External Links

PubMed source DOI: 10.1128/iai.3.2.287-294.1971 PMC Full Text View journal details

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Nonencapsulated Variant of Cryptococcus neoformans I. Virulence Studies and Characterization of Soluble Polysaccharide.

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