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PMID: 16622295 Published · ppublish English Journal Article Review

Adipocyte-derived hormones, cytokines, and mediators.

Endocrine ·Vol. 29 ·No. 1 ·2006-02-00 ·Pages 81-90

Rondinone CM

Abstract

Adipose tissue is responsive to both central and peripheral metabolic signals and is itself capable of secreting a number of proteins. These adipocyte-specific or enriched proteins, termed adipokines, have been shown to have a variety of local, peripheral, and central effects. These secreted proteins, which include tumor necrosis factor (TNF)-alpha, resistin, IL-6, IL-8, acylation-stimulating protein (ASP), angiotensinogen, plasminogen activator inhibitor-1 (PAI-1) ("bad" adipokines) and leptin, adiponectin ("good" adipokines) seem to play important regulatory roles in a variety of complex processes, including fat metabolism, feeding behavior, hemostasis, vascular tone, energy balance, and insulin sensitivity, but none is without controversy regarding its respective mechanism and scope of action. The present review is focused on the effects of free fatty acids and a restricted number of adipokines, which have been implicated in vascular (angiotensinogen, PAI-1) and energy and glucose homeostasis (ASP, TNFalpha, IL-6, resistin, leptin, adiponectin).

MeSH Terms
Adipocytes/metabolism Adiponectin/physiology Adipose Tissue/drug effects,physiology Anti-Obesity Agents/pharmacology,therapeutic use Cardiovascular Physiological Phenomena Cytokines/physiology Energy Metabolism/drug effects,physiology Fatty Acids, Nonesterified/physiology Glucose/metabolism Homeostasis/drug effects,physiology Humans Intercellular Signaling Peptides and Proteins/physiology Leptin/physiology Obesity/drug therapy,physiopathology Peptide Hormones/physiology Resistin/physiology
Chemicals
Adiponectin Anti-Obesity Agents Cytokines Fatty Acids, Nonesterified Intercellular Signaling Peptides and Proteins Leptin Peptide Hormones Resistin Glucose
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Rondinone Cristina M
Department Metabolic Diseases, Hoffmann-La Roche, Nutley, New Jersey 07110, USA. [email protected]
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Article Info
Journal
Endocrine
Abbr.
Endocrine
ISSN
1355-008X
DOI
10.1385/endo:29:1:81
Email
[email protected]
Published
2006-02-00
Pages
81-90
Language
English
Region
United States
NLM ID
9434444
Subset
IM
External Links
PubMed source DOI: 10.1385/endo:29:1:81 View journal details
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