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PMID: 1671710 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Adenovirus type 5 E1A gene products act as transformation suppressors of the neu oncogene.

Molecular and cellular biology ·Vol. 11 ·No. 3 ·1991-03-00 ·Pages 1745-50

Yu DH, Scorsone K, Hung MC

Abstract

The adenovirus type 5 early region 1A (E1A) gene was introduced into neu-transformed B104-1-1 cells. Cells that expressed E1A possessed reduced transforming activity in vitro and reduced tumorigenicity in nude mice. These results demonstrate that the E1A gene products can act negatively to suppress the transformed phenotype in neu-transformed cells.

MeSH Terms
Adenovirus Early Proteins Animals Blotting, Southern Cell Division Cell Line Cell Transformation, Neoplastic Gene Expression Mice Mice, Nude Neoplasms, Experimental/genetics Oncogene Proteins, Viral/physiology Oncogenes Proto-Oncogene Proteins/genetics Receptor, ErbB-2 Transfection
Chemicals
Adenovirus Early Proteins Oncogene Proteins, Viral Proto-Oncogene Proteins Receptor, ErbB-2
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Yu D H
Department of Tumor Biology, University of Texas M.D. Anderson Cancer Center, Houston 77030.
Scorsone K
Hung M C
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33 references, click to expand
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Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.11.3.1745-1750.1991
Published
1991-03-00
Pages
1745-50
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC369488
Subset
IM
Grants
NCI NIH HHS · CA-45265 · United States
External Links
PubMed source DOI: 10.1128/mcb.11.3.1745-1750.1991 PMC Full Text View journal details
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