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PMID: 16742426 Published · ppublish English Journal Article

Substrate stereochemistry in squalene biosynthesis: The first Ciba medal lecture.

The Biochemical journal ·Vol. 101 ·No. 3 ·1966-12-00 ·Pages 553.b4-568

Popják G, Cornforth JW

Abstract

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Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Popják G
Cornforth J W
References (23)
23 references, click to expand
  1. Studies on the biosynthesis of cholesterol. XX. Steric course of decarboxylation of 5-pyrophosphomevalonate and of the carbon to carbon bond formation in the biosynthesis of farnesyl pyrophosphate.
    J Biol Chem. 1966 Sep 10;241(17):3970-87 PMID: 4288360
  2. Sterospecificity of hydrogen transfer from reduced triphosphopyridine nucleotide to squalene during its synthesis from farnesyl pyrophosphate.
    Biochem Biophys Res Commun. 1962 Jan 24;6:438-42 PMID: 14487887
  3. Studies on the biosynthesis of cholesterol XIX. Steric course of hydrogen eliminations and of C-C bond formations in squalene biosynthesis.
    Proc R Soc Lond B Biol Sci. 1966 Jan 18;163(993):492-514 PMID: 4379291
  4. The biological synthesis of cholesterol.
    Science. 1965 Oct 1;150(3692):19-28 PMID: 5319508
  5. Stereochemistry of the exchange catalyzed by succinic dehydrogenase.
    Biochem Biophys Res Commun. 1964 Jun 1;16(2):156-61 PMID: 5871804
  6. Synthesis of phosphatides in isolated mitochondria. III. The enzymatic phosphorylation of glycerol.
    J Biol Chem. 1954 Dec;211(2):951-61 PMID: 13221600
  7. On the structure of the diphosphopyridine nucleotide-cyanide complex.
    J Biol Chem. 1955 Dec;217(2):579-87 PMID: 13271418
  8. Studies on the biosynthesis of cholesterol. 5. Biosynthesis of squalene from DL-3-hydroxy-3-methyl [2-14C] pentano-5-lactone.
    Biochem J. 1958 May;69(1):146-55 PMID: 13535596
  9. [Biosynthesis of terpenes. II. Production of (-)- mevalonic acid by bacterial racemate cleavage].
    Hoppe Seylers Z Physiol Chem. 1958;313:291-5 PMID: 13620246
  10. Purification of mevalonic acid dehydrogenase from rat liver by DEAE-cellulose column chromatography.
    Arch Biochem Biophys. 1961 Apr;93:153-6 PMID: 13727607
  11. Studies on the biosynthesis of cholesterol. XV. Mechanism of squalene biosynthesis from farnesyl pyrophosphate and from mevalonate.
    J Biol Chem. 1961 Jul;236:1934-47 PMID: 13737104
  12. Reduction of mevaldic acid to mevalonic acid by a partially purified enzyme from liver.
    J Biol Chem. 1961 Sep;236:2421-4 PMID: 13747804
  13. Mevalonic acid pyrophosphate and isopentenylpyrophosphate.
    J Biol Chem. 1959 Oct;234:2595-604 PMID: 13801508
  14. Studies on the biosynthesis of cholesterol. XII. Synthesis of allyl pyrophosphates from mevalonate and their conversion into squalene with liver enzymes.
    J Lipid Res. 1960 Jul;1:286-300 PMID: 13851061
  15. Mechanism of the succinic dehydrogenase catalysed reaction.
    Nature. 1963 Mar 30;197:1270-2 PMID: 13946904
  16. Stereospecific insertion of hydrogen atom into squalene from reduced nicotinamide-adenine dinucleotides.
    Biochem Biophys Res Commun. 1963 Apr 23;11:129-34 PMID: 14023096
  17. THE STEREOCHEMISTRY OF THE ISOCITRIC ACID DEHYDROGENASE REACTION.
    Biochem Biophys Res Commun. 1963 Aug 14;12:356-60 PMID: 14070344
  18. THE STEREOCHEMISTRY OF THE GLUTAMATE MUTASE REACTION.
    Ann N Y Acad Sci. 1964 Apr 24;112:655-60 PMID: 14167299
  19. STEREOCHEMICAL COURSE OF THE ISOCITRATE LYASE REACTION.
    J Biol Chem. 1964 Dec;239:4268-71 PMID: 14247681
  20. THE MIGRATION AND ELIMINATION OF HYDROGEN DURING BIOSYNTHESIS OF CHOLESTEROL FROM SQUALENE.
    J Am Chem Soc. 1965 Jul 20;87:3224-8 PMID: 14329430
  21. On the mechanism of formation of isopentenylpyrophosphate.
    Biochemistry. 1962 Jan;1:182-8 PMID: 14465394
  22. Studies on the biosynthesis of cholesterol. XVI. Chemical synthesis of 1-H2-3-2-C-14- and 1-D2-2-C-14-trans-trans-farnesyl pyrophosphate and their utilization in squalene biosynthesis.
    J Biol Chem. 1962 Jan;237:56-61 PMID: 14487886
  23. Studies on the biosynthesis of cholesterol. 18. The stereospecificity of mevaldate reductase and the biosynthesis of asymmetrically labelled farnesyl pyrophosphate.
    Proc R Soc Lond B Biol Sci. 1966 Jan 18;163(993):465-91 PMID: 4379290
Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
Published
1966-12-00
Pages
553.b4-568
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1270154
External Links
PubMed source PMC Full Text View journal details
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