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PMID: 16782013 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Kinetochores use a novel mechanism for coordinating the dynamics of individual microtubules.

Current biology : CB ·Vol. 16 ·No. 12 ·2006-06-20 ·Pages 1217-23

VandenBeldt KJ, Barnard RM, Hergert PJ, Meng X, Maiato H, McEwen BF

Abstract

Chromosome alignment during mitosis is frequently accompanied by a dynamic switching between elongation and shortening of kinetochore fibers (K-fibers) that connect kinetochores and spindle poles . In higher eukaryotes, mature K-fibers consist of 10-30 kinetochore microtubules (kMTs) whose plus ends are embedded in the kinetochore . A critical and long-standing question is how the dynamics of individual kMTs within the K-fiber are coordinated . We have addressed this question by using electron tomography to determine the polymerization/depolymerization status of individual kMTs in the K-fibers of PtK1 and Drosophila S2 cells. Surprisingly, we find that the plus ends of two-thirds of kMTs are in a depolymerizing state, even when the K-fiber exhibits net tubulin incorporation at the plus end . Furthermore, almost all individual K-fibers examined had a mixture of kMTs in the polymerizing and depolymerizing states. Therefore, although K-fibers elongate and shrink as a unit, the dynamics of individual kMTs within a K-fiber are not coordinated at any given moment. Our results suggest a novel control mechanism through which attachment to the kinetochore outer plate prevents shrinkage of kMTs. We discuss the ramifications of this new model on the regulation of chromosome movement and the stability of K-fibers.

MeSH Terms
Animals Chromosomes/metabolism Drosophila/ultrastructure Kinetochores/metabolism,physiology,ultrastructure Microtubules/metabolism,ultrastructure Models, Biological Tomography, X-Ray Computed
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
VandenBeldt Kristin J
Wadsworth Center, New York State Department of Health, Albany, New York 12201, USA.
Barnard Rita M
Hergert Polla J
Meng Xing
Maiato Helder
McEwen Bruce F
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Article Info
Journal
Current biology : CB
Abbr.
Curr Biol
ISSN
0960-9822
Published
2006-06-20
Pages
1217-23
Language
English
Region
England
NLM ID
9107782
PMCID
PMC2906179
Subset
IM
Grants
NIGMS NIH HHS · R01 GM066270-04 · United States
NCRR NIH HHS · P41 RR01219 · United States
NIGMS NIH HHS · R01 GM06627 · United States
NCRR NIH HHS · P41 RR001219 · United States
NIGMS NIH HHS · R01 GM040198 · United States
NIGMS NIH HHS · R01 GM066270 · United States
NIGMS NIH HHS · R01 GM40198 · United States
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