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PMID: 16801391 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Peroxisome biogenesis: the peroxisomal endomembrane system and the role of the ER.

The Journal of cell biology ·Vol. 174 ·No. 1 ·2006-07-03 ·Pages 11-7

Titorenko VI, Mullen RT

Abstract

Peroxisomes have long been viewed as semiautonomous, static, and homogenous organelles that exist outside the secretory and endocytic pathways of vesicular flow. However, growing evidence supports the view that peroxisomes actually constitute a dynamic endomembrane system that originates from the endoplasmic reticulum. This review highlights the various strategies used by evolutionarily diverse organisms for coordinating the flow of membrane-enclosed carriers through the peroxisomal endomembrane system and critically evaluates the dynamics and molecular mechanisms of this multistep process.

MeSH Terms
Animals Endoplasmic Reticulum/metabolism,physiology Humans Intracellular Membranes/metabolism Membrane Proteins/metabolism Models, Biological Peroxisomes/metabolism,physiology
Chemicals
Membrane Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Titorenko Vladimir I
Department of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada.
Mullen Robert T
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47 references, click to expand
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Article Info
Journal
The Journal of cell biology
Abbr.
J Cell Biol
ISSN
0021-9525
DOI
10.1083/jcb.200604036
Published
2006-07-03
Epub
2006-00-26
Pages
11-7
Language
English
Region
United States
NLM ID
0375356
PMCID
PMC2064154
Subset
IM
External Links
PubMed source DOI: 10.1083/jcb.200604036 PMC Full Text View journal details
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